Evidence map›Paper›PMID 39905624›Full record

ArticleJournal of proteome research2025

LC-MS/MS-Profiling of Human Serum Unveils Significant Increase in Neuroinflammation and Carcinogenesis Following Chronic Organophosphate Exposure.

Vishal Sandilya, Dina El-Gameel, Mojgan Atashi, Thu Nguyen, Mojibola Fowowe, Md Mostofa Al Amin Bhuiyan, Oluwatosin Daramola, Judith Nwaiwu, Noha A Hamdy, Maha Ghanem and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of proteome research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Vishal SandilyaDepartment of Chemistry and Biochemistry, Texas Tech University, Lubbock, Texas 79409, United States.
Dina El-GameelDepartment of Pharmacy Practice, Faculty of Pharmacy, Alexandria University, Alexandria, Egypt.
Mojgan AtashiDepartment of Chemistry and Biochemistry, Texas Tech University, Lubbock, Texas 79409, United States.
Thu NguyenDepartment of Chemistry and Biochemistry, Texas Tech University, Lubbock, Texas 79409, United States.
Mojibola FowoweDepartment of Chemistry and Biochemistry, Texas Tech University, Lubbock, Texas 79409, United States.
Md Mostofa Al Amin BhuiyanDepartment of Chemistry and Biochemistry, Texas Tech University, Lubbock, Texas 79409, United States.
Oluwatosin DaramolaDepartment of Chemistry and Biochemistry, Texas Tech University, Lubbock, Texas 79409, United States.
Judith NwaiwuDepartment of Chemistry and Biochemistry, Texas Tech University, Lubbock, Texas 79409, United States.
Noha A HamdyDepartment of Pharmacy Practice, Faculty of Pharmacy, Alexandria University, Alexandria, Egypt.
Maha GhanemDepartment of Forensic Medicine and Clinical Toxicology, Faculty of Medicine, Alexandria University, Alexandria, Egypt.
Labiba K El-KhordaguiDepartment of Pharmaceutics, Faculty of Pharmacy, Alexandria University, Alexandria, Egypt.
Salwa M AbdallahCenter of Excellence for Toxicological Testing, Department of Mammalian and Aquatic Toxicology, Central Agricultural Pesticides Lab (CAPL), Agricultural Research Center (ARC), Giza, Egypt.
Ahmed El-YazbiDepartment of Pharmacology and Toxicology, Faculty of Pharmacy, Alexandria, Egypt.
Yehia MechrefDepartment of Chemistry and Biochemistry, Texas Tech University, Lubbock, Texas 79409, United States.ORCID 0000-0002-6661-6073

Funding

Quantitative Characterization of Glycopeptide IsomersR01GM130091 · NIGMS · TEXAS TECH UNIVERSITY · PI Yehia Mechref · 2019 to 2026
$2.5M
Screening of Glycan Markers in Serum for Early Detection of HCC in Different Etiologies of DiseaseU01CA225753 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI LUBMAN, DAVID M., MECHREF, YEHIA · 2018 to 2021
$2.0M
NCI NIH HHS U01 CA225753NIGMS NIH HHS R01 GM130091
6 · The paper itself

Abstract

The utilization of organophosphate pesticides (OPs) has escalated in response to the growing global food demand driven by a rapidly increasing population and the environmental disruptions caused by climate change. While acute exposure leads to cholinergic poisoning, chronic OP exposure has been linked to organ dysfunction, inflammation, and carcinogenesis. Serum samples from healthy individuals (

Indexed as

CarcinogenesisInflammationNeuroinflammatory DiseasesOrganophosphatesAdultCase-Control StudiesChromatography, LiquidFemaleHumansLiquid Chromatography-Mass SpectrometryMaleMiddle AgedPesticidesTandem Mass SpectrometryOrganophosphatesPesticidesblood-serum proteomicscarcinogenesisinflammationLC-MS/MSorganophosphate exposure

Identifiers

PMID39905624
PMCPMC12814890

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.