ArticleArchives of public health = Archives belges de sante publique2025
Role of cognitive impairment in predicting the long-term risk of all-cause mortality: a 20-year prospective cohort study in China.
Article in Archives of public health = Archives belges de sante publique, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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9 citing papers in PubMed.
- Possible osteosarcopenia is associated with loss in intrinsic capacity and early cognitive deficits: a longitudinal study of older adults in Singapore.The journals of gerontology. Series A, Biological sciences and medical sciences · 2026Article
- Cognitive function in patients undergoing robotic radical prostatectomy - 1 year follow up.Journal of robotic surgery · 2026Article
- Development of a clinical nomogram to assess the risk of cognitive impairment in community-dwelling middle-aged and older adults.BMC neurology · 2026Article
- Article
- Sex-specific trajectories and variability of pain burden in relation to cognitive decline and depressive symptoms in older adults: a prospective cohort study from health and retirement study.BMC public health · 2025Article
- Exploring the potential relationship between kidney disease index and cognitive dysfunction: a machine learning approach with NHANES data.BMC geriatrics · 2025Article
- Multivariate decomposition of gender differentials in cognitive impairment among older adults in India based on Longitudinal Ageing Study in India, 2017-2018.BMC psychiatry · 2025Article
- Combined impact of neutrophil-to-high-density lipoprotein cholesterol ratio (NHR) and cognitive function on all-cause mortality in older adults: a population-based study.Lipids in health and disease · 2025Article
- Analysis of urban-rural differences in cognitive function among empty nest older adult in China based on Blinder-Oaxaca decomposition.Frontiers in public health · 2025Article
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Abstract
backgroundThere is limited evidence of the relationship between cognitive changes and all-cause mortality. And it has no report of population-attributable fraction (PAF) of mortality due to cognitive impairment in Chinese elderly. In light of this, we comprehensively examined the relationship between cognitive impairment and all-cause mortality after 20-year follow-up among the elderly Chinese.
methodsThis is an epidemiological survey with a 20-year prospective cohort study design. A total of 9093 participants came from the Chinese Longitudinal Healthy Longevity Survey 1998-2018 waves. Cox proportional hazards regressions were performed to analyze the relationship between baseline cognitive impairment status, the rate of change in the MMSE scores over two years and subsequent all-cause mortality.
resultsWe observed a dose-response relationship between cognition and mortality. Compared to those with no impairment, elderly with mild (AHR = 1.11, 95% CI 1.05-1.18), moderate (AHR = 1.22, 95% CI 1.13-1.33) and severe (AHR = 1.30, 95% CI 1.19-1.42) cognitive impairment showed increased mortality risk. Elderly with rapid cognitive decline had 24% higher mortality risk than those with stable cognitive (AHR = 1.24, 95%CI 1.10-1.39). The PAF of mortality due to severe cognitive impairment was 3.69% (95%CI:2.36-5.25%). Impairment in the subdomain of naming foods (AHR = 1.12, 95% CI 1.04-1.21), registration (AHR = 1.18, 95% CI 1.11-1.26), attention and calculation (AHR = 1.13, 95% CI 1.07-1.21), copy figure (AHR = 1.13, 95% CI 1.06-1.20), delayed recall (AHR = 1.14, 95% CI 1.07-1.20) and language (AHR = 1.14, 95% CI 1.05-1.24) were independently associated with increased mortality risk among participants.
conclusionBaseline cognitive impairment was inversely associated with longevity among the elderly Chinese. The rapid cognitive decline increased all-cause mortality, and this risk would continue for 20 years. These findings underscore the crucial role of early detection and management of cognitive impairment in the elderly.
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