ArticleBMC psychology2025
Influence of symptom burden on social alienation in lung cancer patients receiving chemotherapy: the chain mediating effect of perceived social support and positive psychological capital.
Article in BMC psychology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- The lived experiences of social isolation among cancer patients: a systematic review and meta-synthesis.International journal of nursing studies advances · 2026Review
- The multidimensional impact of malnutrition in incurable cancer.Current opinion in supportive and palliative care · 2026Review
- The Association Between Social Support and Psychosomatic Status in Cancer Patients During Mid-Course Radiotherapy: The Chain Mediating Roles of Psychological Capital and Coping Styles.Healthcare (Basel, Switzerland) · 2026Article
- A study on the association between psychological capital and dyadic coping among lung cancer patients and their caregivers: an actor-partner interdependence model approach.Frontiers in psychology · 2026Article
- Experiences of psychosomatic symptoms and self-management strategies among patients with advanced lung cancer undergoing chemotherapy: a qualitative study based on symptom management theory.Frontiers in public health · 2026Article
- Social support and demoralization among patients with lung cancer in China: A moderated mediation model of self-efficacy and symptom distress.Asia-Pacific journal of oncology nursing · 2025Article
- Relationship between stigma, psychological resilience, and social alienation in patients with advanced lung cancer and their caregivers: An actor-partner interdependence mediation model.Asia-Pacific journal of oncology nursing · 2025Article
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6 authors.
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Abstract
backgroundSocial alienation is prevalent among lung cancer (LC) patients undergoing chemotherapy. Although previous research has established an association between social alienation and symptom burden, the mechanisms underlying this relationship remain not fully understood.
methodsThis cross-sectional study used convenience sampling to select 378 LC patients undergoing chemotherapy from September 2022 to December 2023 at a tertiary care hospital in Guangzhou, China. Data collection was conducted using a proprietary Sociodemographic Information Questionnaire, MD Anderson Symptom Inventory (MDASI), Social Alienation Questionnaire, Perceptions of Social Support (PSS) Questionnaire, and Positive Psychological Capital (PPC) Questionnaire. To analyze chain-mediated effects, the PROCESS v3.3 Model 6 SPSS macro software was employed.
resultsThe analysis revealed that the burden of symptoms significantly exacerbates social alienation, as evidenced in the mediation effects model (Bootstrap 95% CI: 0.031, 0.092). Furthermore, the burden of symptoms indirectly diminishes PSS (Bootstrap 95% CI: 0.019, 0.057) and PPC (Bootstrap 95% CI: 0.002, 0.020). It is crucial to note that both PSS and PPC significantly mediate the relationship between symptom burden and social alienation, as evidenced (Bootstrap 95% CI: 0.001, 0.011).
conclusionsThe impact of symptom burden on social alienation is moderated through PSS and PPC, manifesting both directly and indirectly. Moreover, the influence of PPC tends to mitigate the mediating role of PSS. Clinical interventions aimed at bolstering PSS and augmenting PPC may potentially alleviate social alienation and enhance the quality of life for patients undergoing chemotherapy for LC.
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