Observational studyEuropean journal of medical research2025
L-shaped association between ankle-brachial index and coronary heart disease in Chinese adults with hypertension.
Observational study in European journal of medical research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Ankle-Brachial Index as a Predictor of Cardiovascular and Cerebrovascular Events in Hypertension: A Systematic Review.Research in heart yield and translational medicine · 2026Review
- Correlation Between Cardiac Troponin Serum Concentration and Selected Parameters of Subclinical Cardiovascular Dysfunction in Patients With and Without Arterial Hypertension: Retrospective Cross-Sectional Analysis of Real-World Data.Journal of clinical medicine · 2025Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
backgroundPrior research has established that an ankle-brachial index (ABI) ≤ 0.9 is positively correlated with cardiovascular events, including coronary heart disease (CHD). The present study aimed to elucidate the dose-response relationship between ABI and CHD within a hypertensive population.
methodsWe conducted a cross-sectional analysis involving 10,900 hypertensive patients, with CHD as the primary outcome. A generalized additive model (GAM) and fitted smoothing curve were employed to assess linearity and delineate the dose-response association between ABI and CHD.
resultsThe cohort had a mean (SD) age of 68.3 (9.25) years, with 5129 (47.06%) being male. CHD was present in 552 (5.06%) participants. The fully adjusted odds ratio (OR) for CHD associated with ABI levels was 0.75 (95%CI 0.33-1.71). An L-shaped relationship between ABI and CHD was identified, with an inflection point at 1.07. Below this threshold, ABI showed a negative correlation with CHD (OR: 0.27; 95%CI 0.08-0.84), whereas above it, the association was not significant (OR: 3.08; 95%CI 0.60-15.80).
conclusionsIn Chinese adults with hypertension, ABI exhibits a nonlinear, L-shaped association with CHD, with the inflection point at 1.07.
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