ArticleCritical care (London, England)2025
Trendelenburg position is a reasonable alternative to passive leg raising for predicting volume responsiveness in mechanically ventilated patients in the ICU.
Article in Critical care (London, England), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Trendelenburg maneuver to predict fluid responsiveness in patients under mechanical ventilation with spontaneous breathing: a prospective study.BMC anesthesiology · 2026Article
- Changes in internal jugular vein respiratory variation during tidal volume challenge predict volume responsiveness in lumbar surgery under protective ventilation: a prospective cohort study.Journal of intensive care · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
backgroundPassive leg raising (PLR) is a well-recognized method for assessing volume responsiveness in the intensive care unit (ICU); however, it has some limitations. The physiology of the cardiac preload induced by the Trendelenburg position and PLR is similar. The Trendelenburg position can be initiated from the supine position and then tilted downward (TREND
methodsThe study was a prospective single-center cohort study conducted in a comprehensive ICU. The study consisted of the following sequential steps: (1) baseline-1: supine position with a 0° bed angulation; (2) Trendelenburg position: 15° downward bed angulation; (3) baseline-2: the same position as baseline-1; (4) reverse Trendelenburg position: 15° upward bed angulation; (5) Trendelenburg position: 15° downward bed angulation; (6) baseline-3: the same position as baseline-1; (7) semi-recumbent position: trunk elevated at 45°; (8) PLR: lower limbs elevated at 45° and trunk in the supine position; (9) baseline-4: the same position as baseline-1; (10) volume loading test: 250 ml of 4% albumin was infused over 10 min. At each time point, hemodynamic parameters were monitored using pulse contour analysis. A positive volume response was defined as an increase of at least 15% in SVI on pulse contour monitoring from baseline-4 after the volume loading test. The receiver operating characteristic curves were performed for ΔSVI.
resultsIn this study, 36 patients were included for analysis, and of these, 15 patients (42%) were volume-responsive. TREND
conclusionsThe Trendelenburg position (TREND
trial registrationChiCTR2300067694. Registered on January 18, 2023.
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