Evidence map›Paper›PMID 39905414›Full record

ArticleWorld journal of surgical oncology2025

Cytoplasmic SALL4-A isoform expression as a diagnostic marker of less aggressive tumor behavior in gastric cancer.

Saeed Rahmani, Amirhesam Babajani, Maryam Abolhasani, Roya Ghods, Elham Kalantari, Zahra Madjd

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Article in World journal of surgical oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1citing papers in PubMed
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1 · What the graph read from it

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3 · Its place in the literature

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1 citing paper in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Saeed RahmaniOncopathology Research Center, Iran University of Medical Sciences, Tehran, Iran.
Amirhesam BabajaniOncopathology Research Center, Iran University of Medical Sciences, Tehran, Iran.
Maryam AbolhasaniOncopathology Research Center, Iran University of Medical Sciences, Tehran, Iran.
Roya GhodsOncopathology Research Center, Iran University of Medical Sciences, Tehran, Iran.
Elham KalantariOncopathology Research Center, Iran University of Medical Sciences, Tehran, Iran.
Zahra MadjdOncopathology Research Center, Iran University of Medical Sciences, Tehran, Iran. majdjabari.z@iums.ac.ir.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundGastric cancer (GC) poses significant challenges globally, ranking fifth in incidence and fourth in cancer-related mortality. SALL4, a stem cell transcription factor with multiple isoforms, includes SALL4-A as its full-length form. This study aims to evaluate the diagnostic potential of SALL4-A isoform expression in GC and its clinical significance.

methodImmunohistochemical (IHC) analysis was conducted on Tissue Micro Array (TMA) slides from 167 GC patients. Clinicopathological parameters were correlated with SALL4-A expression, and survival analysis was performed. Diagnostic performance was assessed using metrics such as sensitivity, specificity, and area under the curve (AUC).

resultsSALL4-A exhibited distinct cytoplasmic expression in GC, correlating with lower histological grade (p = 0.003) and TNM stage (p = 0.003), particularly in the intestinal subtype. Diagnostic evaluation showed an AUC of 0.803 for cytoplasmic expression, demonstrating high diagnostic potential. However, SALL4-A expression did not show significant prognostic value.

conclusionCytoplasmic SALL4-A expression in GC is associated with less aggressive tumor phenotypes and shows promise as a diagnostic marker. Further research is warranted to elucidate its mechanistic role and potential integration into clinical practice.

Indexed as

Biomarkers, TumorCytoplasmStomach NeoplasmsTranscription FactorsAdultAgedAged, 80 and overFemaleFollow-Up StudiesHumansMaleMiddle AgedNeoplasm StagingPrognosisProtein IsoformsSurvival RateBiomarkers, TumorProtein IsoformsSALL4 protein, humanTranscription FactorsBiomarkersCancer stem cellGastric cancerImmunohistochemistrySALL4-A

Identifiers

PMID39905414
PMCPMC11796022

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