Evidence map›Paper›PMID 39905329›Full record

ArticleBMC pediatrics2025

Lactate/albumin ratio as a prognostic biomarker for in-hospital mortality in pediatric patients with necrotizing enterocolitis.

Ban Li, Yuanzhi Chen, Zhen Yang, Xianglun Sun, Cheng Tian, Jingsi Liu, Lihua Yuan, Kanglin Dai

2 registry-linked trialsAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07207915 completednot on this map

Analysis of Integrated Clinical, Laboratory and Prognostic Data of Neonates With Necrotizing Enterocolitis

TypeobservationalSponsorSixth Affiliated Hospital, Sun Yat-sen UniversityRan2023 to 2025Enrolled400ConditionsNecrotizing EnterocolitisArmsObservational retrospective cohort study
NCT07249697 completednot on this map

Risk Factors for Poor Prognosis in Neonatal Necrotizing Enterocolitis

TypeobservationalSponsorGuangzhou Women and Children's Medical CenterRan2017 to 2025Enrolled118ConditionsNecrotizing EnterocolitisArmsObservational retrospective cohort study
3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ban Li *Division of Pediatric Surgery, Department of Surgery, The University of Hong Kong-Shenzhen Hospital, ShenZhen, 518053, Guangdong Province, China.
Yuanzhi Chen *The Third Affiliated Hospital of Guangzhou Medical University, GuangZhou, 510150, Guangdong Province, China.
Zhen YangDivision of Pediatric Surgery, Department of Surgery, The University of Hong Kong-Shenzhen Hospital, ShenZhen, 518053, Guangdong Province, China.
Xianglun SunDivision of Pediatric Surgery, Department of Surgery, The University of Hong Kong-Shenzhen Hospital, ShenZhen, 518053, Guangdong Province, China.
Cheng TianDivision of Pediatric Surgery, Department of Surgery, The University of Hong Kong-Shenzhen Hospital, ShenZhen, 518053, Guangdong Province, China.
Jingsi LiuDivision of Pediatric Surgery, Department of Surgery, The University of Hong Kong-Shenzhen Hospital, ShenZhen, 518053, Guangdong Province, China.
Lihua YuanDivision of Pediatric Surgery, Department of Surgery, The University of Hong Kong-Shenzhen Hospital, ShenZhen, 518053, Guangdong Province, China.
Kanglin DaiDivision of Pediatric Surgery, Department of Surgery, The University of Hong Kong-Shenzhen Hospital, ShenZhen, 518053, Guangdong Province, China. kanglindai@126.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo assess the lactate/albumin ratio (L/A) as a prognostic biomarker for differentiating in-hospital mortality risk in pediatric patients with necrotizing enterocolitis (NEC).

methodsWe performed a retrospective study utilizing the Pediatric Intensive Care (PIC) database. Patients diagnosed with NEC were categorized into a discharge group and a death group based on in-hospital outcomes. The association between L/A and in-hospital mortality was assessed using logistic regression models.

resultsAfter inclusion and exclusion criteria, 100 NEC patients were included in the study, with 87 survivors and 13 deaths. The mean age at admission was 21.6 ± 2.4 days, and the mean weight was 2.1 ± 0.1 kg. Significant differences in creatinine, international normalized ratio (INR) and L/A were observed between the groups (p < 0.05). The L/A ratio was a substantial predictor of in-hospital mortality, with an odds ratio (OR) of 5.24 (95% CI: 1.51-18.20, p = 0.01). An L/A cutoff value of 0.56 demonstrated a sensitivity of 0.923 and specificity of 0.486, with an AUC of 0.725 from the ROC curve analysis. Patients with an L/A ratio of ≥ 0.56 had a higher risk of in-hospital mortality (OR = 11.35, 95% CI: 1.40-91.93, p = 0.02).

conclusionOur study suggested that the L/A ratio may serve as a reliable prognostic indicator for in-hospital mortality in NEC. However, given the limitations of our research, more prospective studies are still needed in the future to test the predictive value of L/A ratio for the prognosis of NEC disease. CLINICAL TRIAL NUMBER: Not applicable.

Indexed as

Enterocolitis, NecrotizingHospital MortalityLactic AcidSerum AlbuminBiomarkersFemaleHumansInfantInfant, NewbornLogistic ModelsMalePrognosisRetrospective StudiesROC CurveBiomarkersLactic AcidSerum AlbuminIn-hospital mortalityLactate/albumin ratioNeonatal necrotizing enterocolitisPediatric intensive care database

Identifiers

PMID39905329
PMCPMC11792259

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.