ArticleBMC plant biology2025
Writers, readers, and erasers of N6-Methyladenosine (m6A) methylomes in oilseed rape: identification, molecular evolution, and expression profiling.
Article in BMC plant biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Pathogen-triggered m⁶A epitranscriptomic reprogramming is linked to host defense responses in the Piper nigrum-Phytophthora capsici pathosystem.Plant cell reports · 2026Article
- Comprehensive Genome-Wide Identification and Expression Analysis of the N6-Methyladenosine (m6A) Regulatory Network Influences Rapid Stress Adaptation With Exogenous Melatonin in Rice.Journal of pineal research · 2026Article
- The Central Role of m6A as Epigenetic Regulator in Metabolic Disorders of Therapeutic Potential and Clinical Implications.Molecular neurobiology · 2025Review
- Salt stress mitigating potential of bacterial endophytes isolated from Moringa oleifera.Scientific reports · 2025Article
- Genome-wide identification and characterization of DUF789 genes in cotton: implications for fibre development.BMC plant biology · 2025Article
- Micropropagation ofPlants (Basel, Switzerland) · 2025Article
- Investigating the use of green synthesized copper oxide nanoparticles from Melia azedarach to combat cadmium stress in wheat.Scientific reports · 2025Article
- Protective capacity of Rutin against oxidative damage induced by saline stress in the roots of the model organism Allium cepa.Scientific reports · 2025Article
- Eco-friendly role of serratia marcescens and pseudomonas fluorescens in enhancing rice growth and mitigating cadmium toxicity via uptake modulation and antioxidant regulation.BMC plant biology · 2025Article
- 2OM-Pred: prediction of 2-O-methylation sites in ribonucleic acid using diverse classifiers.Briefings in bioinformatics · 2025Article
- Article
- Gibberellin-mediated internode elongation in grasses with a focus on bamboo: molecular pathways and regulatory networks.Frontiers in plant science · 2025Review
- Epigenetic odyssey to decrypt the hidden code for sustainable brassica production: enhancing yield, stress resilience and nutritional quality.Frontiers in plant science · 2025Review
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Authors and funding
7 authors.
Funding
Abstract
backgroundm6A RNA modifications are the most prevalent internal modifications in eukaryotic mRNAs and are crucial for plant growth and development, as well as for responses to biotic or abiotic stresses. The modification is catalyzed by writers, removed by erasers, and decoded by various m6A-binding proteins, which are readers. Brassica napus is a major oilseed crop. The dynamic regulation of m6A modifications by writers, erasers, and readers offers potential targets for improving the quality of this crop.
resultsIn this study, we identified 92 m6A-regulatory genes in B. napus, including 13 writers, 29 erasers, and 50 readers. A phylogenetic analysis revealed that they could be further divided into four, three, and two clades, respectively. The distribution of protein motifs and gene structures among members of the same clade exhibited notable similarity. During the course of evolution, whole genome duplication (WGD) and segmental duplication were the primary drivers of the expansion of m6A-related gene families. The genes were subjected to rigorous purification selection. Additionally, several sites under positive selection were identified in the proteins. RNA-seq and quantitative real-time PCR (qRT-PCR) expression analyses revealed that the identified Bnam6As exhibit tissue-specific expression patterns, as well as their expression patterns in response to various abiotic and biotic stresses. The 2000 bp sequence upstream of Bnam6As contained a number of cis-acting elements that regulate plant growth and environmental response. Furthermore, the protein interaction network revealed their interactions with a number of proteins of significant functional importance.
conclusionThe identification of m6A modifiers in oilseed rape and their molecular evolution and expression profiling have revealed potential functions and molecular mechanisms of m6A, thus establishing a foundation for further functional validation and molecular breeding.
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