ArticleNature neuroscience2025
The developmental emergence of reliable cortical representations.
Article in Nature neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Interneuron and glial mechanisms underlying V1 orientation map dynamics.IBRO neuroscience reports · 2026Article
- Millimeter-scale selective amplification in the developing visual cortex.bioRxiv : the preprint server for biology · 2026Article
- State-Dependent Dissociation of Shared Input and Directed Information Flow in the Visual Cortex.bioRxiv : the preprint server for biology · 2026Article
- Article
- Connectivity, Computation, and Plasticity of the Early Visual System.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Review
- Temporal coding carries more stable cortical visual representations than firing rate over time.Nature communications · 2025Article
- Retinal waves reveal axial biases in modular patterns of cortical activity that predict future orientation preferences.bioRxiv : the preprint server for biology · 2025Article
- Stereotyped Spatiotemporal Dynamics of Spontaneous Activity in Visual Cortex Prior to Eye Opening.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
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Authors and funding
4 authors.
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Abstract
The fundamental structure of cortical networks arises early in development before the onset of sensory experience. However, how endogenously generated networks respond to the onset of sensory experience and how they form mature sensory representations with experience remain unclear. In this study, we examined this 'nature-nurture transform' at the single-trial level using chronic in vivo calcium imaging in ferret visual cortex. At eye opening, visual stimulation evokes robust patterns of modular cortical network activity that are highly variable within and across trials, severely limiting stimulus discriminability. These initial stimulus-evoked modular patterns are distinct from spontaneous network activity patterns present before and at the time of eye opening. Within a week of normal visual experience, cortical networks develop low-dimensional, highly reliable stimulus representations that correspond with reorganized patterns of spontaneous activity. Using a computational model, we propose that reliable visual representations derive from the alignment of feedforward and recurrent cortical networks shaped by novel patterns of visually driven activity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.