ArticleNature neuroscience2025
Separating cognitive and motor processes in the behaving mouse.
Article in Nature neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- The Tower Foraging Park: A paradigm for studying cognitive and motor processes underlying behavioral flexibility in freely moving mice.iScience · 2026Article
- Article
- Contextual gating of whisker-evoked responses by frontal cortex supports flexible decision making.Nature communications · 2026Article
- Anterior cingulate neurons combine outcome monitoring of past decisions with ongoing movement signals.Nature communications · 2026Article
- Functional bipartition of medial prefrontal cortex into salience detection and movement gain.bioRxiv : the preprint server for biology · 2026Article
- Closed-loop error damping in human BCI using pre-error motor cortex activity.bioRxiv : the preprint server for biology · 2026Article
- How distributed is the brain-wide network that is recruited for cognition?Nature reviews. Neuroscience · 2026Review
- Disrupted cortex-wide dynamics impair motor planning in Shank3-mutant mice.bioRxiv : the preprint server for biology · 2026Article
- Brain-wide analysis reveals movement encoding structured across and within brain areas.Nature neuroscience · 2026Article
- Facial expressions in mice reveal latent cognitive variables and their neural correlates.Nature neuroscience · 2025Article
- Mapping neural subspace dynamics onto the structure of the mouse descending motor system.bioRxiv : the preprint server for biology · 2025Article
- Article
- Dynamical Modeling of Behaviorally Relevant Spatiotemporal Patterns in Neural Imaging Data.ArXiv · 2025Article
- Spontaneous movements and their relationship to neural activity fluctuate with latent engagement states.Neuron · 2025Article
- Cognitive processes are disentangled at cortex-wide scales.bioRxiv : the preprint server for biology · 2025Article
- Dynamical Modeling of Behaviorally Relevant Spatiotemporal Patterns in Neural Imaging Data.Proceedings of machine learning research · 2025Article
- Ramping dynamics in the frontal cortex unfold over multiple timescales during motor planning.Journal of neurophysiology · 2025Article
- Ramping Dynamics in the Frontal Cortex Unfold Over Multiple Timescales During Motor Planning.bioRxiv : the preprint server for biology · 2024Article
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6 authors.
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Abstract
The cognitive processes supporting complex animal behavior are closely associated with movements responsible for critical processes, such as facial expressions or the active sampling of our environments. These movements are strongly related to neural activity across much of the brain and are often highly correlated with ongoing cognitive processes. A fundamental issue for understanding the neural signatures of cognition and movements is whether cognitive processes are separable from related movements or if they are driven by common neural mechanisms. Here we demonstrate how the separability of cognitive and motor processes can be assessed and, when separable, how the neural dynamics associated with each component can be isolated. We designed a behavioral task in mice that involves multiple cognitive processes, and we show that dynamics commonly taken to support cognitive processes are strongly contaminated by movements. When cognitive and motor components are isolated using a novel approach for subspace decomposition, we find that they exhibit distinct dynamical trajectories and are encoded by largely separate populations of cells. Accurately isolating dynamics associated with particular cognitive and motor processes will be essential for developing conceptual and computational models of neural circuit function.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.