Evidence map›Paper›PMID 39905209›Full record

ArticleScientific reports2025

The corpus callosum in people with congenital adrenal hyperplasia (CAH).

Eileen Luders, Debra Spencer, Caitlin Dale, Ieuan A Hughes, Ajay Thankamony, Umasuthan Srirangalingam, Helena Gleeson, Helen Simpson, Melissa Hines, Florian Kurth

Abstract read
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In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Eileen LudersDepartment of Women's and Children's Health, Uppsala University, Uppsala, Sweden. eileen.lueders@uu.se.
Debra SpencerDepartment of Psychology, University of Cambridge, Cambridge, UK.
Caitlin DaleSchool of Psychology, University of Auckland, Auckland, New Zealand.
Ieuan A HughesDepartment of Paediatrics, Addenbrooke's Hospital, University of Cambridge, Cambridge, UK.
Ajay ThankamonyDepartment of Paediatrics, Addenbrooke's Hospital, University of Cambridge, Cambridge, UK.
Umasuthan SrirangalingamDepartment of Endocrinology and Diabetes, University College Hospital London, London, NW1 2BU, UK.
Helena GleesonQueen Elizabeth Hospital, Birmingham, UK.
Helen SimpsonDepartment of Endocrinology and Diabetes, University College Hospital London, London, NW1 2BU, UK.
Melissa HinesDepartment of Psychology, University of Cambridge, Cambridge, UK.
Florian KurthSchool of Psychology, University of Auckland, Auckland, New Zealand.

Funding

Brain and behavior in individuals with intersex conditionsR01HD081720 · NICHD · UNIVERSITY OF CAMBRIDGE · PI HINES, MELISSA, LUEDERS, EILEEN · 2015 to 2020
$1.8M
NICHD NIH HHS R01 HD081720
6 · The paper itself

Abstract

Congenital Adrenal Hyperplasia (CAH) is a group of genetic disorders that affect the adrenal glands. CAH manifests in abnormal levels of cortisol and androgens and is accompanied by white matter alterations. However, no CAH study has specifically targeted the corpus callosum, the brain's largest white matter fiber tract. To bridge that gap in the literature, we investigated callosal morphology in 53 individuals with CAH and 53 matched controls (66 women, 40 men). In addition to calculating areas for seven callosal subsections, we estimated the callosal thickness at 100 equidistant points. All statistical analyses were conducted while co-varying for age and total brain volume and applying corrections for multiple comparisons. There were no significant effects of biological sex and no significant group-by-sex interactions. However, there was a significant effect of group, both for area measures and thickness estimates, indicating smaller dimensions within the callosal splenium and isthmus in people with CAH. Our findings corroborate previous studies highlighting white matter alterations in CAH and may suggest that callosal integrity is compromised due to potentially adverse effects of glucocorticoids, a standard treatment for both men and women with CAH.

Indexed as

Adrenal Hyperplasia, CongenitalCorpus CallosumAdolescentAdultCase-Control StudiesFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedWhite MatterYoung AdultAndrogensCorpus callosumCorticosteroidDevelopmentMagnetic resonance imagingSex

Identifiers

PMID39905209
PMCPMC11794586

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.