ArticleNature immunology2025
Terminal differentiation and persistence of effector regulatory T cells essential for preventing intestinal inflammation.
Abstract read
In one paragraph
Article in Nature immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed.
- Regulatory T cells in cancer and inflammation.Signal transduction and targeted therapy · 2026Review
- Article
- Marine Polysaccharides Modulating the Gut Microbiota-Immune Axis in Digestive Tract Tumors: An Update.Marine drugs · 2026Review
- Identification and characterization of dietary antigens in oral tolerance.Science immunology · 2026Article
- Article
- Macrophage membrane-biomimetic cinnamaldehyde nanomedicine ameliorates inflammatory bowel disease by suppressing macrophage M1 polarization.Theranostics · 2026Article
- Beyond Foxp3 and TSDR: a dual epigenetic lock framework for treg stability and plasticity.Frontiers in immunology · 2026Review
- Ubiquitin-Modifying Enzymes as Cell-Fate Regulators in Intestinal Inflammation.International journal of biological sciences · 2026Review
- IL-27 promotes Treg cell expression of CD122 and fitness at homeostasis.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Enkephalin-producing regulatory T cells in the skin restrain local inflammation through control of nociception.Science immunology · 2025Article
- Dectin-1-targeted pH-responsive liposomal nanoplatform delivering Plantago Asiatica L. acidic polysaccharide for immunomodulation and immunosuppressive breast cancer microenvironment reprogramming.Journal of nanobiotechnology · 2025Article
- Immunopathological and microbial signatures of inflammatory bowel disease in partial RAG deficiency.The Journal of experimental medicine · 2025Article
- CD4 T cell therapy counteracts inflammaging and senescence by preserving gut barrier integrity.Science immunology · 2025Article
- Thetis cells: regulators of intestinal immune tolerance.Current opinion in immunology · 2025Review
- Role of human antigen-specific T cells in tolerance and IgE-mediated allergic reactions to food.Frontiers in immunology · 2025Review
- Deciphering the regulatory mechanisms of honeysuckle (Frontiers in immunology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors.
Stanislav DikiyHoward Hughes Medical Institute and Immunology Program, Ludwig Center at Memorial Sloan Kettering Cancer Center, New York, NY, USA. sdikiy@scripps.edu.ORCID http://orcid.org/0000-0002-8287-6561
Aazam P GhelaniHoward Hughes Medical Institute and Immunology Program, Ludwig Center at Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Andrew G LevineHoward Hughes Medical Institute and Immunology Program, Ludwig Center at Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Stephen MartisComputational Oncology, Department of Epidemiology & Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID http://orcid.org/0000-0003-1735-2347
Paolo GiovanelliHoward Hughes Medical Institute and Immunology Program, Ludwig Center at Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID http://orcid.org/0000-0002-5799-6721
Zhong-Min WangHoward Hughes Medical Institute and Immunology Program, Ludwig Center at Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID http://orcid.org/0000-0002-5538-1969
Giorgi BeroshviliHoward Hughes Medical Institute and Immunology Program, Ludwig Center at Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Yuri PritykinComputational and Systems Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID http://orcid.org/0000-0001-6589-981X
Chirag KrishnaComputational and Systems Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Xiao HuangHoward Hughes Medical Institute and Immunology Program, Ludwig Center at Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Ariella GlasnerHoward Hughes Medical Institute and Immunology Program, Ludwig Center at Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Benjamin D GreenbaumComputational Oncology, Department of Epidemiology & Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID http://orcid.org/0000-0001-6153-8793
Christina S LeslieComputational and Systems Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID http://orcid.org/0000-0002-4571-5910
Alexander Y RudenskyHoward Hughes Medical Institute and Immunology Program, Ludwig Center at Memorial Sloan Kettering Cancer Center, New York, NY, USA. rudenska@mskcc.org.ORCID http://orcid.org/0000-0003-1280-2898
Funding
X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4MThe Center for Tumor-Immune Systems Biology at MSKCCU54CA274492 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI Christina S Leslie · 2022 to 2026
$16.3MSELF PEPTIDES BOUND TO MHC CLASS II IN T CELL SELECTIONR01AI034206 · NIAID · UNIVERSITY OF WASHINGTON · PI Alexander Y Rudensky · 1998 to 2026
$6.4MRegulatory genomics of T cells in mouse and humanDP2AI171161 · NIAID · PRINCETON UNIVERSITY · PI Yury Pritykin · 2022 to 2026
$2.4MHoward Hughes Medical Institute (HHMI) HHMI0Ludwig Institute for Cancer Research (Ludwig Cancer Research) Ludwig0NCI NIH HHS P30 CA008748NCI NIH HHS U54 CA274492NIAID NIH HHS DP2 AI171161NIAID NIH HHS R01 AI034206
Abstract
Regulatory T (T
Indexed as
Cell DifferentiationColitisColonT-Lymphocytes, RegulatoryAnimalsInflammationInterleukin-10MiceMice, Inbred C57BLMice, KnockoutMice, TransgenicReceptors, Antigen, T-CellSignal TransductionInterleukin-10Receptors, Antigen, T-Cell
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LicenceCC BY
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.