Evidence map›Paper›PMID 39905023›Full record

ArticleNature communications2025

Dendritic excitations govern back-propagation via a spike-rate accelerometer.

Pojeong Park, J David Wong-Campos, Daniel G Itkis, Byung Hun Lee, Yitong Qi, Hunter C Davis, Benjamin Antin, Amol Pasarkar, Jonathan B Grimm, Sarah E Plutkis and 4 more

Abstract read
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Review
  10. Review
  11. Kv4.2The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026
    Article
  12. Article
  13. A dendrite-resolved,bioRxiv : the preprint server for biology · 2026
    Article
  14. Article
  15. Review
  16. The grand challenge in cellular neurophysiology.Frontiers in cellular neuroscience · 2026
    Article
  17. Behavioral Timescale Synaptic Plasticity: A Burst in the Field of Learning and Memory.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors.

Pojeong Park *Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA.ORCID http://orcid.org/0000-0002-5574-6104
J David Wong-Campos *Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA.
Daniel G ItkisDepartment of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA.
Byung Hun LeeDepartment of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA.
Yitong QiDepartment of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA.
Hunter C DavisDepartment of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA.
Benjamin AntinDepartments of Statistics and Neuroscience, Columbia University, New York, NY, USA.
Amol PasarkarDepartments of Statistics and Neuroscience, Columbia University, New York, NY, USA.
Jonathan B GrimmJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, USA.ORCID http://orcid.org/0000-0003-0331-4200
Sarah E PlutkisJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, USA.ORCID http://orcid.org/0009-0003-1822-0466
Katie L HollandJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, USA.
Liam PaninskiDepartments of Statistics and Neuroscience, Columbia University, New York, NY, USA.
Luke D LavisJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, USA.
Adam E CohenDepartment of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA. cohen@chemistry.harvard.edu.ORCID http://orcid.org/0000-0002-8699-2404

Funding

Two-Photon All-Optical Electrophysiology in Behaving MiceRF1NS126043 · NINDS · HARVARD UNIVERSITY · PI COHEN, ADAM EZRA · 2022 to 2022
$2.2M
Chemigenetic voltage indicators for far-red and two-photon imaging in vivoRF1NS133755 · NINDS · BROWN UNIVERSITY · PI ABDELFATTAH, AHMED · 2023 to 2023
$2.2M
Brain-wide correlation of single-cell firing properties to patterns of gene expressionRF1MH117042 · NIMH · HARVARD UNIVERSITY · PI COHEN, ADAM EZRA · 2018 to 2018
$1.2M
NIMH NIH HHS RF1 MH117042NINDS NIH HHS RF1 NS126043NINDS NIH HHS RF1 NS133755U.S. Department of Health & Human Services | National Institutes of Health (NIH) R01-MH117042U.S. Department of Health & Human Services | National Institutes of Health (NIH) R01-NS126043
6 · The paper itself

Abstract

Dendrites on neurons support electrical excitations, but the computational significance of these events is not well understood. We developed molecular, optical, and computational tools for all-optical electrophysiology in dendrites. We mapped sub-millisecond voltage dynamics throughout the dendritic trees of CA1 pyramidal neurons under diverse optogenetic and synaptic stimulus patterns, in acute brain slices. Our data show history-dependent spike back-propagation in distal dendrites, driven by locally generated Na

Indexed as

Action PotentialsDendritesPyramidal CellsAnimalsCA1 Region, HippocampalCalcium ChannelsMaleMiceMice, Inbred C57BLNeuronal PlasticityOptogeneticsReceptors, N-Methyl-D-AspartateSodiumSynapsesCalcium ChannelsReceptors, N-Methyl-D-AspartateSodium

Identifiers

PMID39905023
PMCPMC11794848

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.