ArticleESC heart failure2025
Prognostic impact of gait speed, muscle strength and muscle mass in chronic heart failure-A prospective cohort study.
Article in ESC heart failure, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Beyond Total Body Muscle Mass: The Necessity of Incorporating Muscle Function for Risk Stratification in Heart Failure.Geriatrics & gerontology international · 2026Article
- Differential increase in peak oxygen uptake with cardiac rehabilitation among patients with stage B versus C heart failure.European journal of physical and rehabilitation medicine · 2026Observational
- Body composition phenotypes and phase angle as predictors of mortality in subjects with right ventricular dysfunction: a prospective cohort study.Frontiers in nutrition · 2026Article
- Prognostic value of Short Physical Performance Battery in older patients with Stage B heart failure: a prospective cohort study.BMC geriatrics · 2025Article
- Prognostic impact of gait speed, muscle strength and muscle mass in chronic heart failure-A prospective cohort study.ESC heart failure · 2025Article
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Authors and funding
18 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsHeart failure (HF) impairs skeletal muscle mass and function, which contributes to reduced physical performance. We investigated the prognostic impact of gait speed (GS), handgrip strength (HG) and appendicular skeletal muscle index (ASMI) on cardiovascular outcomes in a prospective HF cohort.
methodsThis single-centre prospective cohort study included adults with stable chronic HF with a previous diagnosis of overtly reduced left ventricular ejection fraction (LVEF) <40% and LVEF < 50% at enrolment. GS was measured by the 4 m GS test, maximal HG was measured with a hydraulic dynamometer, and ASMI was measured by dual-energy X-ray absorptiometry. The primary combined outcome was cardiovascular death or worsening HF. Fine and Gray regression models were calculated, treating non-cardiovascular death as the competing event.
resultsTwo hundred five patients (78% male) were analysed. The median age was 66 (quartiles: 58-74) years, 31% had diabetes mellitus, and the median LVEF was 37 (30-43) %. Median GS was 1.0 (0.8-1.0) m/s, median HG was 32 (24-40) kg, and median ASMI was 8.0 (7.2-8.9) kg/m
conclusionsHigher GS was independently associated with a lower risk of cardiovascular death or worsening HF, whereas HG and ASMI were not. We prospectively confirm GS as a physical performance measure with clear prognostic significance for patients with HF.
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