Evidence map›Paper›PMID 39904906›Full record

ArticleEuropean journal of nutrition2025

Serum homocysteine is a biomarker for hearing loss associated with or without cardiovascular risk: a cross-sectional study in men.

Carmen Morais-Moreno, Isabel García-Perez, Sara Bueno, María Luisa Sánchez, Ana M Montero-Bravo, Ana M Puga, Lourdes Samaniego-Vaesken, Mar Ruperto, Rocío Marco-Mendez, Álvaro Vicente-Arche and 2 more

Abstract read
In one paragraph

Article in European journal of nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Carmen Morais-MorenoGrupo USP-CEU de Excelencia "Nutrición Para la Vida (Nutrition for life)", Ref: E02/0720, Departamento de Ciencias Farmacéuticas y de la Salud, Facultad de Farmacia, Universidad San Pablo-CEU, CEU Universities, Urbanización Montepríncipe, Boadilla del Monte, 28660, Spain.ORCID http://orcid.org/0000-0002-1289-3745
Isabel García-PerezSection of Nutrition, Digestion and Reproduction, Faculty of Medicine, Imperial College London, London, UK.ORCID http://orcid.org/0000-0001-8398-0603
Sara BuenoDepartamento de Química Aplicada y Bioquímica, Facultad de Farmacia, Universidad San Pablo-CEU, CEU Universities, Urbanización Montepríncipe, Boadilla del Monte, 28660, Spain.ORCID http://orcid.org/0000-0001-5329-8312
María Luisa SánchezDepartamento de Química Aplicada y Bioquímica, Facultad de Farmacia, Universidad San Pablo-CEU, CEU Universities, Urbanización Montepríncipe, Boadilla del Monte, 28660, Spain.ORCID http://orcid.org/0000-0002-2542-0381
Ana M Montero-BravoGrupo USP-CEU de Excelencia "Nutrición Para la Vida (Nutrition for life)", Ref: E02/0720, Departamento de Ciencias Farmacéuticas y de la Salud, Facultad de Farmacia, Universidad San Pablo-CEU, CEU Universities, Urbanización Montepríncipe, Boadilla del Monte, 28660, Spain.ORCID http://orcid.org/0000-0001-5103-3732
Ana M PugaGrupo USP-CEU de Excelencia "Nutrición Para la Vida (Nutrition for life)", Ref: E02/0720, Departamento de Ciencias Farmacéuticas y de la Salud, Facultad de Farmacia, Universidad San Pablo-CEU, CEU Universities, Urbanización Montepríncipe, Boadilla del Monte, 28660, Spain.ORCID http://orcid.org/0000-0003-2836-4642
Lourdes Samaniego-VaeskenGrupo USP-CEU de Excelencia "Nutrición Para la Vida (Nutrition for life)", Ref: E02/0720, Departamento de Ciencias Farmacéuticas y de la Salud, Facultad de Farmacia, Universidad San Pablo-CEU, CEU Universities, Urbanización Montepríncipe, Boadilla del Monte, 28660, Spain.ORCID http://orcid.org/0000-0001-7323-4420
Mar RupertoGrupo USP-CEU de Excelencia "Nutrición Para la Vida (Nutrition for life)", Ref: E02/0720, Departamento de Ciencias Farmacéuticas y de la Salud, Facultad de Farmacia, Universidad San Pablo-CEU, CEU Universities, Urbanización Montepríncipe, Boadilla del Monte, 28660, Spain.ORCID http://orcid.org/0000-0002-8790-4007
Rocío Marco-MendezCentro de Instrucción de Medicina Aeroespacial (CIMA), Madrid, Spain.
Álvaro Vicente-ArcheCentro de Instrucción de Medicina Aeroespacial (CIMA), Madrid, Spain.
Gregorio Varela-Moreiras *Grupo USP-CEU de Excelencia "Nutrición Para la Vida (Nutrition for life)", Ref: E02/0720, Departamento de Ciencias Farmacéuticas y de la Salud, Facultad de Farmacia, Universidad San Pablo-CEU, CEU Universities, Urbanización Montepríncipe, Boadilla del Monte, 28660, Spain. gvarela@ceu.es.ORCID http://orcid.org/0000-0001-5158-4999
Teresa Partearroyo *Grupo USP-CEU de Excelencia "Nutrición Para la Vida (Nutrition for life)", Ref: E02/0720, Departamento de Ciencias Farmacéuticas y de la Salud, Facultad de Farmacia, Universidad San Pablo-CEU, CEU Universities, Urbanización Montepríncipe, Boadilla del Monte, 28660, Spain. t.partearroyo@ceu.es.ORCID http://orcid.org/0000-0002-4401-1233

Funding

Santander Universities MCP19V07 and MCP20V13
6 · The paper itself

Abstract

purposeHearing loss (HL) represents a major health problem worldwide, and increasingly so due to population ageing and new leisure activities, such as video gaming or virtual reality experiences. HL has a multifactorial origin including both genetic and environmental issues with nutrition status emerging as a new contributing factor. In fact, certain micronutrient deficiencies, along with excessive consumption of specific macronutrients, have been related to HL This study aimed to examine the association of HL with dietary fat intake, nutritional status biomarkers, and serum metabolic signature in aviation pilots and controls.

methodsA cohort of aviation pilots, chronically exposed to noise pollution at work, was compared to a cohort of non-exposed university workers (controls). Hearing function was determined by tonal audiometry and dietary fat intake was assessed by three 24-h recalls. In addition, lipoprotein profiles as well as serum homocysteine (Hcy), folate, vitamins B

resultsHL prevalence was similar and elevated in both cohorts (controls: 64% vs. noise-exposed: 65%), when compared to the American Speech-Language-Hearing Association (ASHA) classification. When comparing both cohorts, although no significant differences were found in Hcy and folate levels, controls had significantly lower vitamins B

conclusionFolate insufficiency together with hyperhomocysteinemia increased susceptibility to noise-induced HL. However, the role of Hcy in HL without noise exposure at work seems to be partially masked by an altered CV profile.

Indexed as

Cardiovascular DiseasesHearing LossHomocysteineAdultBiomarkersCohort StudiesCross-Sectional StudiesDietary FatsFolic AcidHeart Disease Risk FactorsHumansMaleMiddle AgedNutritional StatusVitamin B 12Vitamin DBiomarkersDietary FatsFolic AcidHomocysteineVitamin B 12Vitamin DCardiovascular riskFolateHearing lossHomocysteineLipoproteinsVitamin D

Identifiers

PMID39904906
PMCPMC11794339

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.