Evidence map›Paper›PMID 39904900›Full record

ArticleAnalytical and bioanalytical chemistry2025

International co-validation of glycated hemoglobin A1c certified reference materials.

Chengxiang Ning, Ji-Seon Jeong, Tomoya Kinumi, Kazumi Saikusa, Megumi Kato, Youxun Jin, Bin Yang, Jing Wang, Liqing Wu

Abstract readValidation Study
PubMed Publisher
In one paragraph

Article in Analytical and bioanalytical chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Chengxiang NingCenter for Advanced Measurement Science, National Institute of Metrology, Beijing, 100029, China.
Ji-Seon JeongOrganic Metrology Group, Division of Chemical and Material Metrology, Korea Research Institute of Standards and Science (KRISS), 267 Gajeong-Ro, Yusung-Gu, Daejeon, 34113, Republic of Korea.
Tomoya KinumiNational Metrology Institute of Japan, National Institute of Advanced Industrial Science and Technology (AIST), 1-1-1 Umezono C3-9, Tsukuba, Ibaraki, 305-8563, Japan.
Kazumi SaikusaNational Metrology Institute of Japan, National Institute of Advanced Industrial Science and Technology (AIST), 1-1-1 Umezono C3-9, Tsukuba, Ibaraki, 305-8563, Japan.
Megumi KatoNational Metrology Institute of Japan, National Institute of Advanced Industrial Science and Technology (AIST), 1-1-1 Umezono C3-9, Tsukuba, Ibaraki, 305-8563, Japan.
Youxun JinCenter for Advanced Measurement Science, National Institute of Metrology, Beijing, 100029, China.
Bin YangCenter for Advanced Measurement Science, National Institute of Metrology, Beijing, 100029, China.
Jing WangCenter for Advanced Measurement Science, National Institute of Metrology, Beijing, 100029, China. wj@nim.ac.cn.
Liqing WuCenter for Advanced Measurement Science, National Institute of Metrology, Beijing, 100029, China. wulq@nim.ac.cn.

Funding

Guangdong NQI Quality and Safety Technology Collaborative Innovation Project 2018B020207007-2Internal funding of the National Institute of Metrology (NIM), P. R. China AKY1509
6 · The paper itself

Abstract

Accurate quantification of glycated hemoglobin A1c (HbA1c) is essential for the diagnosis and glycemic control in diabetic patients. The validation of HbA1c certified reference material (CRM) enhances the accuracy and comparability of HbA1c measurements. An international co-validation of HbA1c CRMs was conducted among the National Institute of Metrology, P.R. China (NIM), the Korea Research Institute of Standards and Science (KRISS), and the National Metrology Institute of Japan (NMIJ). Candidate reference materials (RMs) of VHLTPE, glycated VHLTPE, and two levels of HbA1c were developed and supplied by NIM. NIM investigated the homogeneity and stability of these materials, finding no inhomogeneity and confirming stability throughout the co-validation period. Isotope dilution mass spectrometry was employed for the quantitation of both hexapeptides in solution and HbA1c in a matrix. All three national metrology institutes (NMIs) were involved in the quantification of hexapeptides in solution, whereas only NIM and KRISS were involved in the quantification of HbA1c in the matrix. E

Indexed as

Glycated HemoglobinHumansMass SpectrometryReference StandardsReproducibility of ResultsGlycated Hemoglobinhemoglobin A1c protein, humanCertified reference materialCo-validationGlycated hemoglobin A1cHbA1cHexapeptidesIsotope dilution mass spectrometry

Identifiers

PMID39904900

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.