ArticleAnnals of biomedical engineering2025
Multi-Scale Multi-Cell Computational Model of Inflammation-Mediated Aortic Remodeling in Hypertension.
Article in Annals of biomedical engineering, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Postnatal pulmonary artery development from transcript to tissue.Journal of the Royal Society, Interface · 2026Article
- A multiscale computational model of ascending thoracic aortic aneurysm development in Marfan syndrome for in silico trials.Biomechanics and modeling in mechanobiology · 2026Article
- Aortic dissection as a disease of vascular wall homeostasis: integrating vasa vasorum-inflammation-metabolism axis for mechanistic insight and clinical translation.Frontiers in immunology · 2026Review
- Ascending aortic aneurysm growth in the Fbln4Biomechanics and modeling in mechanobiology · 2025Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
purposeMultiple cell types interact within the aortic wall to control development, homeostasis, and adaptation as well as to drive disease progression. Given the complexity of these interactions and their manifestations at the tissue level, there is a pressing need for a new class of computational models that integrate data across scales.
methodsWe meld logic-based cell signaling models of vascular smooth muscle cells, adventitial fibroblasts, and macrophages and couple this multi-cell model with a tissue level-constrained mixture model of aortic growth and remodeling. The coupled multi-scale model is parameterized using data from the literature and then specialized for the case of angiotensin II-induced hypertensive remodeling of the descending thoracic aorta in wild-type mice.
resultsWe contrast important contributions of chemo- and mechano-stimulation of cell responses and identify critical roles of recruited macrophages in driving the non-homeostatic thickening of the adventitial layer that reduces biaxial wall stress below setpoint values.
conclusionWe show the utility of a multi-scale, multi-cell model in delineating effects of different chemo-mechanical stimuli in aortic remodeling in hypertension.
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Registered trials
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