Evidence map›Paper›PMID 39904853›Full record

ArticlePharmaceutical research2025

Dietary phytochemical indole-3-carbinol regulates metabolic reprogramming in mouse prostate tissue.

Rebecca Mary Peter, Md Shahid Sarwar, Lujing Wang, Pochung Chou, Chao Wang, Yujue Wang, Xiaoyang Su, Ah-Ng Kong

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pharmaceutical research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Rebecca Mary Peter *Department of Pharmaceutics, Ernest Mario School of Pharmacy, The State University of New Jersey, RutgersPiscataway, NJ, 08854, USA.
Md Shahid Sarwar *Department of Pharmaceutics, Ernest Mario School of Pharmacy, The State University of New Jersey, RutgersPiscataway, NJ, 08854, USA.
Lujing Wang *Department of Pharmaceutics, Ernest Mario School of Pharmacy, The State University of New Jersey, RutgersPiscataway, NJ, 08854, USA.
Pochung ChouDepartment of Pharmaceutics, Ernest Mario School of Pharmacy, The State University of New Jersey, RutgersPiscataway, NJ, 08854, USA.
Chao WangDepartment of Pharmaceutics, Ernest Mario School of Pharmacy, The State University of New Jersey, RutgersPiscataway, NJ, 08854, USA.
Yujue WangMetabolomics Shared Resource, Rutgers Cancer Institute of New Jersey, New Brunswick, NJ, 08901, USA.
Xiaoyang SuMetabolomics Shared Resource, Rutgers Cancer Institute of New Jersey, New Brunswick, NJ, 08901, USA.
Ah-Ng KongDepartment of Pharmaceutics, Ernest Mario School of Pharmacy, The State University of New Jersey, RutgersPiscataway, NJ, 08854, USA. kongt@pharmacy.rutgers.edu.ORCID http://orcid.org/0000-0002-9273-4217

Funding

Translational Research Support CoreP30ES005022 · NIEHS · UNIV OF MED/DENT NJ-R W JOHNSON MED SCH · PI BRIAN T BUCKLEY · 1988 to 2026
$47.4M
Epigenetic mechanisms of indole-3-carbinol/diindolylemthane and triterpenoids in prevention of prostate inflammation and related diseaseR01AT009152 · NCCIH · RUTGERS, THE STATE UNIV OF N.J. · PI KONG, AH-NG TONY · 2015 to 2019
$3.3M
NCCIH NIH HHS R01 AT009152NIEHS NIH HHS P30 ES005022
6 · The paper itself

Abstract

purposeIndole-3-carbinol (I3C) is shown to possess multiple pharmacological activities such as anti-inflammatory, antimicrobial, antioxidant, antiviral, and anti-cancer activities. It is widely accepted as modulator of multiple signaling pathways particularly those related to cell cycle, cell growth and division, angiogenesis, apoptosis and immunity. We explored the metabolic reprogramming based on treatment with I3C in mice prostate tissue.

methodsIn this study we utilized Pten knockout (KO)-induced prostate tumorigenesis mouse model to examine mechanism of action of I3C via metabolic rewiring. Phosphatase and tensin homolog deleted on chromosome 10 (Pten), a tumor suppressor gene is frequently found to be mutated or deleted in prostate cancer. Untargeted metabolomics was performed using liquid-chromatography mass-spectrometry (LC-MS) based platform to investigate Pten-dependent and Pten-independent metabolic targets of I3C.

resultsThe most impacted pathways by I3C included pyrimidine metabolism, arginine and proline metabolism, porphyrin metabolism, citrate cycle and lipoic acid metabolism.

conclusionThese pathways taken together help in understanding the overall health beneficial effects of I3C.

Indexed as

IndolesPhytochemicalsProstateProstatic NeoplasmsAnimalsMaleMetabolic ReprogrammingMetabolomicsMiceMice, Inbred C57BLMice, KnockoutPTEN Phosphohydrolaseindole-3-carbinolIndolesPhytochemicalsPTEN PhosphohydrolasePten protein, mouseIndole-3-carbinolNrf2prostate cancerPtenuntargeted metabolomics

Identifiers

PMID39904853
PMCPMC11880055

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.