Evidence map›Paper›PMID 39904820›Full record

ArticleIntensive care medicine experimental2025

Repeated positron emission tomography tracing neutrophil elastase in a porcine intensive-care sepsis model.

Frida Wilske, Olof Eriksson, Rose-Marie Amini, Sergio Estrada, Helena Janols, Amina Khalil, Anders Larsson, Miklós Lipcsey, Sara Mangsbo, Jonathan Sigfridsson and 6 more

Abstract read
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In one paragraph

Article in Intensive care medicine experimental, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Frida WilskeDepartment of Medical Sciences, Infectious Diseases, Uppsala University, Uppsala, Sweden. frida.wilske@medsci.uu.se.ORCID http://orcid.org/0000-0002-2633-4063
Olof ErikssonScience for Life Laboratory, Department of Medicinal Chemistry, Uppsala University, Uppsala, Sweden.
Rose-Marie AminiDepartment of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden.
Sergio EstradaDepartment of Medicinal Chemistry, Uppsala University, Uppsala, Sweden.
Helena JanolsDepartment of Medical Sciences, Infectious Diseases, Uppsala University, Uppsala, Sweden.
Amina KhalilScience for Life Laboratory, Department of Medicinal Chemistry, Uppsala University, Uppsala, Sweden.
Anders LarssonDepartment of Medical Sciences, Clinical Chemistry, Uppsala University, Uppsala, Sweden.
Miklós LipcseyDepartment of Surgical Sciences, Anaesthesiology and Intensive Care, Uppsala University, Uppsala, Sweden.
Sara MangsboDepartment of Pharmacy, Uppsala University, Uppsala, Sweden.
Jonathan SigfridssonDepartment of Surgical Sciences, Molecular Imaging and Medical Physics, Uppsala University, Uppsala, Sweden.
Jan SjölinDepartment of Medical Sciences, Infectious Diseases, Uppsala University, Uppsala, Sweden.
Paul SkorupDepartment of Medical Sciences, Infectious Diseases, Uppsala University, Uppsala, Sweden.
Anders WallDepartment of Surgical Sciences, Molecular Imaging and Medical Physics, Uppsala University, Uppsala, Sweden.
Viola WilsonDepartment of Medicinal Chemistry, Uppsala University, Uppsala, Sweden.
Markus Castegren *Department of Medical Sciences, Infectious Diseases, Uppsala University, Uppsala, Sweden.
Gunnar Antoni *Department of Medicinal Chemistry, Uppsala University, Uppsala, Sweden.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundNeutrophil granulocytes are important parts of the defence against bacterial infections. Their action is a two-edged sword, the mediators killing the intruding bacteria are at the same time causing tissue damage. Neutrophil activation is part of the dysregulated immune response to infection defining sepsis and neutrophil elastase is one of the powerful proteases causing both effects and damage. Inhibition of neutrophil elastase has been tried in sepsis and ARDS, so far with inconclusive results.

methodsWe used positron emission tomography (PET) combined with computed tomography (CT) and the selective and specific neutrophil elastase inhibitor PET-tracer [

resultsAt baseline [

conclusionThe neutrophil elastase PET-tracer [

Indexed as

[11C]GW457427[11C]NESE coliNeutrophil elastasePETPorcineSepsis

Identifiers

PMID39904820
PMCPMC11794750

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.