Evidence map›Paper›PMID 39904554›Full record

ArticleOpen heart2025

Tissue Doppler echocardiography predicts long-term cardiovascular mortality: the Anglo-Scandinavian Cardiac Outcomes Trial (ASCOT) legacy 20-year follow-up study.

Anenta Ratneswaren, Tong Wu, Amit Kaura, Devan Wasan, Somayeh Rostamian, Andrew Sharp, Neil R Poulter, P S Sever, Alice Stanton, Simon Thom and 4 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Open heart, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Observational
  2. Review
  3. Functional, molecular, and digital measurements of biological age.The Journal of clinical investigation · 2026
    Review
  4. Cardiovascular function in women with previous gestational diabetes mellitus and dysglycemia at 5 months postpartum.Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Anenta RatneswarenNational Heart and Lung Institute, Imperial College London, London, UK.ORCID http://orcid.org/0000-0002-1467-3578
Tong WuNational Heart and Lung Institute, Imperial College London, London, UK.
Amit KauraNational Heart and Lung Institute, Imperial College London, London, UK.
Devan WasanNational Heart and Lung Institute, Imperial College London, London, UK.ORCID http://orcid.org/0009-0007-8132-9201
Somayeh RostamianNational Heart and Lung Institute, Imperial College London, London, UK.
Andrew SharpUniversity Hospital of Wales, Cardiff, UK, Cardiff, UK.
Neil R PoulterNational Heart and Lung Institute, Imperial College London, London, UK.
P S SeverNational Heart and Lung Institute, Imperial College London, London, UK.
Alice StantonMolecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, Dublin, Ireland.
Simon ThomNational Heart and Lung Institute, Imperial College London, London, UK.
Darrel FrancisNational Heart and Lung Institute, Imperial College London, London, UK.
Alun D HughesUniversity College London, London, UK.
Anoop Sv ShahImperial College Healthcare NHS Trust, London, UK.ORCID http://orcid.org/0000-0002-2825-3419
Jamil MayetNational Heart and Lung Institute, Imperial College London, London, UK j.mayet@imperial.ac.uk.

Funding

British Heart Foundation FS/CRA/22/23036
6 · The paper itself

Abstract

backgroundLeft ventricular diastolic function as assessed by tissue Doppler echocardiography predicts cardiovascular event rates at 4 years of follow-up in patients with hypertension. Our aim was to evaluate whether this extends to predicting cardiovascular mortality after 20 years of follow-up.

methodsConventional (E) and tissue Doppler (e') echocardiography was performed on hypertensive participants in the Anglo-Scandinavian Cardiac Outcomes Trial (ASCOT) with long-term follow-up ascertained via linkage to the Office of National Statistics. Cardiovascular mortality was defined as death from coronary heart disease, stroke and other cardiovascular aetiology such as heart failure or peripheral vascular disease. Unadjusted and adjusted Cox regression survival models were constructed to investigate the association between tissue Doppler echocardiography measurements and long-term cardiovascular mortality.

resultsAmong 506 hypertensive patients (median age 64, interquartile range (58, 69), 87% male), there were 200 (40%) deaths over a 20-year follow-up period. 60 deaths (12%) were cardiovascular-related.A reduction in e' was independently associated with increased cardiovascular mortality, after adjusting for the ACC/AHA Atherosclerotic Cardiovascular Disease (ASCVD) risk score, with an inverse HR of 1.22 per 1 cm/s decrease (95% CI 1.04-1.43). A higher E/e' ratio was independently associated with increased cardiovascular mortality, after adjusting for the ASCVD risk score, with an HR of 1.12 per 1-unit increase (95% CI, 1.02 to 1.23).

conclusionsImpaired left ventricular diastolic function, measured using tissue Doppler echocardiography through e' and E/e', independently predicts increased cardiovascular mortality over 20 years in hypertensive patients, highlighting its long-term prognostic significance.

Indexed as

Cardiovascular DiseasesEchocardiography, DopplerHypertensionVentricular Function, LeftAgedFemaleFollow-Up StudiesHumansMaleMiddle AgedPredictive Value of TestsPrognosisRisk AssessmentRisk FactorsSurvival RateTime FactorsEchocardiographyHeart Failure, DiastolicHypertensionRISK FACTORS

Identifiers

PMID39904554
PMCPMC11795408

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