ArticleClinical biomechanics (Bristol, Avon)2025
Differential gait features across Parkinson's disease clinical subtypes.
Article in Clinical biomechanics (Bristol, Avon), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundClinical subtypes in Parkinson's disease including non-motor manifestations may be more beneficial than subtypes based upon motor manifestations alone. Inclusion of gait metrics may help identity targets for rehabilitation and potentially predict development of non-motor symptoms for individuals with Parkinson's disease. This study aims to characterize gait differences across established multi-domain subtypes.
methods"Motor Only", "Psychiatric & Motor" and "Cognitive & Motor" clinical subtypes were established through motor, cognitive, and psychiatric assessment. Walking was assessed in the "OFF" medication state. Multivariate analysis of variance identified differences in gait domains across clinical subtypes.
findingsThe "Motor Only" subtype exhibited the fastest velocity, longest step length, and least timing variability (swing, step, stance), compared to "Psychiatric & Motor" and "Cognitive & Motor" subtypes. Stance time differed across subtypes; "Psychiatric & Motor" subtype had the longest stance time, followed by "Cognitive & Motor", then "Motor only". The "Psychiatric & Motor" group had different asymmetry from the "Cognitive & Motor" subtype, as "Psychiatric & Motor" walked with longer steps on their less-affected side while the "Cognitive & Motor" subtype displayed the opposite pattern. No differences were observed for swing time, step velocity variability, step length variability, width measures, or other asymmetry measures.
interpretationCognitive and Psychiatric subtypes displayed worse gait performance than the "Motor only" group. Stance time and step length asymmetry were different between Psychiatric and Cognitive subtypes, indicating gait deficits may be related to distinct aspects of non-motor manifestations. Gait signatures may help clinicians distinguish between non-motor subtypes, guiding personalized treatment.
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