ArticleCell reports2025
Repetitive antigen stimulation in the periphery dictates the composition and recall responses of brain-resident memory CD8
Abstract read
In one paragraph
Article in Cell reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed.
- Antigen-specific CD8 T cells accumulate and functionally reactivate in the bone marrow following brain infection.Journal of neuroinflammation · 2026Article
- Whole-body irradiation causes long-term impairments in the maintenance and function of naïve CD4 T cells specific for self- and non-self-antigens.Journal of immunology (Baltimore, Md. : 1950) · 2026Article
- TMEM119+ microglia MHC class I restricted antigen presentation impacts CD8 T cell memory, effector status, and blood-brain barrier disruption during neurotropic virus infection.Research square · 2026Article
- Living rent free in your head: resident memory T cells.ImmunoHorizons · 2026Review
- Immune signaling and function in neurodegeneration.The Journal of clinical investigation · 2026Review
- Peripheral vaccination-induced brain-resident memory CD8+ T cells durably protect mice against intracranial malignancy.The Journal of clinical investigation · 2026Article
- Lymph node resident memory T cells retain effector capabilities by evading lung resident memory dysfunction.bioRxiv : the preprint server for biology · 2026Article
- Brain-infiltrating CD8 T cells retain functional activity to protect against acute Zika virus infection.Scientific reports · 2026Article
- Differentiation-induced reduction in functional diversity restricts the ability of cytomegalovirus-specific CD8 T cells to eliminate virus-infected cells.EBioMedicine · 2026Article
- Antigen-specific CD8 T cells are generated and reactivated in the bone marrow following viral brain infections and impact the bone marrow niche.bioRxiv : the preprint server for biology · 2025Article
- High-Dimensional Single-Cell Analysis Reveals Coordinated Age-Dependent Neuroinflammatory Microglia-T cell Circuits in the Brain.bioRxiv : the preprint server for biology · 2025Article
- Physiological microbial exposure normalizes memory T cell surveillance of the brain and modifies host seizure outcomes.Nature immunology · 2025Article
- Peripheral infection wires T cells in the brain.Nature immunology · 2025Article
- CXCR4 and CXCR6 dually limit T cell entry into the polyomavirus-infected brain.Journal of neuroinflammation · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Madison R MixDepartment of Pathology, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA; Medical Scientist Training Program, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA; Interdisciplinary Graduate Program in Immunology, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA.
Stephanie van de WallDepartment of Pathology, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA.
Mohammad HeidarianDepartment of Pathology, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA; Experimental Pathology Graduate Program, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA.
Elizabeth A EscueDepartment of Pathology, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA; Experimental Pathology Graduate Program, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA.
Cori E FainDepartment of Pathology, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA.
Lecia L PeweDepartment of Pathology, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA.
Lisa S HancoxDepartment of Pathology, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA.
Sahaana A ArumugamDepartment of Pathology, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA; Medical Scientist Training Program, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA; Interdisciplinary Graduate Program in Immunology, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA.
Cassie M SieversDepartment of Pathology, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA.
Vladimir P BadovinacDepartment of Pathology, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA; Medical Scientist Training Program, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA; Interdisciplinary Graduate Program in Immunology, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA; Experimental Pathology Graduate Program, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA.
John T HartyDepartment of Pathology, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA; Medical Scientist Training Program, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA; Interdisciplinary Graduate Program in Immunology, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA; Experimental Pathology Graduate Program, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA. Electronic address: john-harty@uiowa.edu.
Funding
Medical Scientist Training ProgramT32GM139776 · NIGMS · UNIVERSITY OF IOWA · PI Gordon F Buchanan · 2021 to 2026
$6.4MINTERDISCIPLINARY IMMUNOLOGY TRAINING PROGRAMT32AI007260 · NIAID · UNIVERSITY OF IOWA · PI BUTLER, NOAH SULLIVAN, WU, LI · 1986 to 2023
$5.7MMemory CD8 T cell localization and protection from influenzaR01AI114543 · NIAID · UNIVERSITY OF IOWA · PI BADOVINAC, VLADIMIR P, HARTY, JOHN T · 2015 to 2024
$4.4MT resident memory in the lungR01AI042767 · NIAID · UNIVERSITY OF IOWA · PI HARTY, JOHN T · 1998 to 2023
$4.4MImmunity to Liver-stage malariaR01AI167847 · NIAID · UNIVERSITY OF IOWA · PI John T Harty · 2022 to 2026
$3.0MCellular and molecular mechanisms controlling sepsis-induced immunoparalyses stateR35GM134880 · NIGMS · UNIVERSITY OF IOWA · PI BADOVINAC, VLADIMIR P · 2020 to 2024
$1.9MBrain T cell interactions in microbial experienced miceR21AI185067 · NIAID · UNIVERSITY OF IOWA · PI HARTY, JOHN T · 2024 to 2025
$428kRegulating Pathogen-induced Protective and Pathogenic CD8 T cells in the CNSR21AI178159 · NIAID · UNIVERSITY OF IOWA · PI HARTY, JOHN T · 2023 to 2024
$414kNIAID NIH HHS R01 AI042767NIAID NIH HHS R01 AI114543NIAID NIH HHS R01 AI167847NIAID NIH HHS R21 AI178159NIAID NIH HHS R21 AI185067NIAID NIH HHS T32 AI007260NIGMS NIH HHS R35 GM134880NIGMS NIH HHS T32 GM139776
Abstract
The human brain harbors virus-specific, tissue-resident memory (T
Indexed as
AntigensBrainCD8-Positive T-LymphocytesImmunologic MemoryMemory T CellsAnimalsHumansMiceMice, Inbred C57BLAntigensbrain T(RM)CP: ImmunologyCP: Neuroscienceinfluenza virusneuroimmunologyrepetitive antigen stimulationviral infection
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.