Trial reportInternational journal of surgery (London, England)2025
ChatGPT's role in alleviating anxiety in total knee arthroplasty consent process: a randomized controlled trial pilot study.
Trial report in International journal of surgery (London, England), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Generative AI Mental Health Chatbots as Therapeutic Tools: Systematic Review and Meta-Analysis of Their Role in Reducing Mental Health Issues.Journal of medical Internet research · 2025Pooled it
- Evaluating and Validating Large Language Models for Health Education on Developmental Dysplasia of the Hip: 2-Phase Study With Expert Ratings and a Pilot Randomized Controlled Trial.Journal of medical Internet research · 2026Trial
- Analgesic Efficacy of Continuous Bupivacaine Infusion versus Liposomal Bupivacaine in Parasacral Ischial Plane Block After Total Knee Arthroplasty: An Open-Label, Randomized, Controlled, Non-Inferiority Study.Drug design, development and therapy · 2026Trial
- Review
- Artificial Intelligence in Arthroplasty: A Comprehensive Structured Critical Review and Descriptive Evidence Map of Validation, Uncertainty, and Workflow Integration.Bioengineering (Basel, Switzerland) · 2026Review
- Osteoarthritis: Epidemiology, Diagnosis, and Treatment.MedComm · 2026Review
- Large Language Model-Assisted Shared Decision-Making (SDM) in Rhinology: A Randomized Controlled Pilot Study.Laryngoscope investigative otolaryngology · 2026Article
- Effectiveness of AI and rule-based conversational agents for depression, anxiety and stress: A meta-analysis.NPJ digital medicine · 2026Article
- Comprehensive Evaluation of AI Consent Forms in Otolaryngologic Surgery.World journal of otorhinolaryngology - head and neck surgery · 2026Article
- Application of artificial intelligence-assisted education for postoperative pulmonary rehabilitation: a hybrid model of AI and nurse-driven support.Journal of cardiothoracic surgery · 2026Article
- The potential, perils and pitfalls of Artificial intelligence (AI) in Assisted Reproductive Technologies (ART).Reproductive biology and endocrinology : RB&E · 2026Review
- Effectiveness of large language models in preoperative and discharge education: a systematic review based on an evaluation framework.NPJ digital medicine · 2026Article
- A commentary on the impact of ChatGPT-assisted total knee arthroplasty consent process on anxiety: a valid intervention or digital placebo?International journal of surgery (London, England) · 2026Article
- Temporal evolution of large language models (LLMs) in oncology.Journal of translational medicine · 2025Article
- Large language models in clinical trials: applications, technical advances, and future directions.BMC medicine · 2025Review
- Artificial intelligence fails to outperform orthopaedic surgeons: A systematic review.Journal of experimental orthopaedics · 2025Review
- Comments on "ChatGPT's role in alleviating anxiety in total knee arthroplasty consent process: a randomized controlled trial pilot study".International journal of surgery (London, England) · 2025Article
- Improving physician-AI collaboration in the informed consent process: insights from a pilot study.Annals of medicine and surgery (2012) · 2025Article
- Videos in short-video sharing platforms as sources of information on osteoarthritis: cross-sectional content analysis study.Frontiers in digital health · 2025Article
- The impact of nurse-led, AI-assisted perioperative health education on psychological status and quality of life in patients undergoing lung cancer surgery.Frontiers in psychology · 2025Article
Corrections and comments
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Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRecent advancements in artificial intelligence (AI) like ChatGPT have expanded possibilities for patient education, yet its impact on perioperative anxiety in total knee arthroplasty (TKA) patients remains unexplored.
methodsIn this single-blind, randomized controlled pilot study from April to July 2023, 60 patients were randomly allocated using sealed envelopes to either ChatGPT-assisted or traditional surgeon-led informed consent groups. In the ChatGPT group, physicians used ChatGPT 4.0 to provide standardized, comprehensive responses to patient queries during the consent process, while maintaining their role in interpreting and contextualizing the information. Outcomes were measured using Hospital Anxiety and Depression Scales (HADS), Perioperative Apprehension Scale-7 (PAS-7), Visual Analogue Scales for Anxiety and Pain (VAS-A, VAS-P), Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), and satisfaction questionnaires.
resultsOf 55 patients completing the study, the ChatGPT group showed significantly lower anxiety scores after informed consent (HADS-A: 10.48 ± 3.84 vs 12.75 ± 4.12, P = .04, Power = .67; PAS-7: 12.44 ± 3.70 vs 14.64 ± 2.11, P = .01, Power = .85; VAS-A: 5.40 ± 1.89 vs 6.71 ± 2.27, P = .02, Power = .75) and on the fifth postoperative day (HADS-A: 8.33 ± 3.20 vs 10.71 ± 3.83, P = .01, Power = .79; VAS-A: 3.41 ± 1.58 vs 4.64 ± 1.70, P = .008, Power = .85). The ChatGPT group also reported higher satisfaction with preoperative education (4.22 ± 0.51 vs 3.43 ± 0.84, P <.001, Power = .99) and overall hospitalization experience (4.11 ± 0.65 vs 3.46 ± 0.69, P = .001, Power = .97). No significant differences were found in depression scores, knee function, or pain levels.
conclusionsChatGPT-assisted informed consent effectively reduced perioperative anxiety and improved patient satisfaction in TKA patients. While these preliminary findings are promising, larger studies are needed to validate these results and explore broader applications of AI in preoperative patient education.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.