Evidence map›Paper›PMID 39903447›Full record

ArticleInfection and immunity2025

Zinc-limited

Endrei Marcantonio, Allexa D Burger, Kelly H Chang, Fukun W Hoffmann, Yuanyuan Fu, Vedbar S Khadka, Benoit J Smagghe, Youping Deng, Peter R Hoffmann, Sladjana Prisic

Abstract read
In one paragraph

Article in Infection and immunity, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Endrei MarcantonioSchool of Life Sciences, University of Hawai'i at Mānoa, Honolulu, Hawaii, USA.ORCID 0000-0002-6718-2326
Allexa D BurgerSchool of Life Sciences, University of Hawai'i at Mānoa, Honolulu, Hawaii, USA.
Kelly H ChangSchool of Life Sciences, University of Hawai'i at Mānoa, Honolulu, Hawaii, USA.ORCID 0009-0009-8396-1782
Fukun W HoffmannDepartment of Cell and Molecular Biology, John A. Burns School of Medicine, University of Hawai'i at Mānoa, Honolulu, Hawaii, USA.
Yuanyuan FuDepartment of Quantitative Health Sciences, John A. Burns School of Medicine, University of Hawai'i at Mānoa, Honolulu, Hawaii, USA.ORCID 0000-0001-7715-0558
Vedbar S KhadkaDepartment of Quantitative Health Sciences, John A. Burns School of Medicine, University of Hawai'i at Mānoa, Honolulu, Hawaii, USA.
Benoit J SmaggheSchool of Life Sciences, University of Hawai'i at Mānoa, Honolulu, Hawaii, USA.ORCID 0009-0009-8872-7995
Youping DengDepartment of Quantitative Health Sciences, John A. Burns School of Medicine, University of Hawai'i at Mānoa, Honolulu, Hawaii, USA.
Peter R HoffmannDepartment of Cell and Molecular Biology, John A. Burns School of Medicine, University of Hawai'i at Mānoa, Honolulu, Hawaii, USA.
Sladjana PrisicSchool of Life Sciences, University of Hawai'i at Mānoa, Honolulu, Hawaii, USA.ORCID 0000-0003-3137-4358

Funding

UH Hilo COP A&RP20GM103466 · NIGMS · UNIVERSITY OF HAWAII AT MANOA · PI Peter R Hoffmann · 2012 to 2026
$60.3M
The Role of gp120 on Cardiovascular Disease in People Living with HIVU54MD007601 · NIMHD · UNIVERSITY OF HAWAII AT MANOA · PI JoAnn Umilani Tsark · 2017 to 2026
$59.5M
Tracking and Evaluation CoreU54GM138062 · NIGMS · UNIVERSITY OF HAWAII AT MANOA · PI SHIKUMA, CECILIA M. · 2021 to 2025
$15.5M
Transgenic Mouse, ICSI and IVF CoreP20GM103457 · NIGMS · UNIVERSITY OF HAWAII AT MANOA · PI WARD, WILLIAM S · 2012 to 2018
$12.9M
The Role of Selenoprotein I in Phospholipidethanolamine Dependent Mechanisms that Regulate T Cell ActivationR01AI147496 · NIAID · UNIVERSITY OF HAWAII AT MANOA · PI HOFFMANN, PETER R · 2019 to 2023
$2.1M
Role of the alternative ribosomes in Mycobacterium tuberculosis adaptationR21AI109293 · NIAID · UNIVERSITY OF HAWAII AT MANOA · PI PRISIC, SLADJANA · 2016 to 2017
$389k
American Lung Association (ALA) IA-937538HHS | National Institutes of Health (NIH) R01AI147496HHS | National Institutes of Health (NIH) R21AI109293HHS | National Institutes of Health (NIH) U54MD007601National Science Foundation (NSF) 1844854NIAID NIH HHS R01 AI147496NIAID NIH HHS R21 AI109293NIGMS NIH HHS P20 GM103457NIGMS NIH HHS P20 GM103466NIGMS NIH HHS U54 GM138062NIMHD NIH HHS U54 MD007601
6 · The paper itself

Abstract

Tuberculosis (TB) is notoriously difficult to treat, likely due to the complex host-pathogen interactions driven by pathogen heterogeneity. An understudied area of TB pathogenesis is host responses to

Indexed as

MacrophagesMycobacterium tuberculosisTuberculosisZincAnimalsHost-Pathogen InteractionsHumansMiceMice, Inbred C57BLPhagocytosisRAW 264.7 CellsReactive Oxygen SpeciesReactive Oxygen SpeciesZincmacrophagesMycobacterium tuberculosiszinc

Identifiers

PMID39903447
PMCPMC11895486

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.