Evidence map›Paper›PMID 39903442›Full record

ArticleOncology and therapy2025

The Impact and Performance of the Molecular Tumor Board: Three-Year Activity in Precision Medicine for Treatment of Patients with Cancer from the Marche Region, in Italy.

Veronica Agostinelli, Giada Torresi, Valentina Tarantino, Gaia Goteri, Alessandra Filosa, Francesca Barbisan, Elisa Bartoli, Francesca Bianchi, Natalia Chiodi, Elisa Ambrosini and 11 more

Abstract read
In one paragraph

Article in Oncology and therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Targeting tumor transition windows.Exploration of targeted anti-tumor therapy · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Veronica AgostinelliDepartment of Clinical and Molecular Sciences, Università Politecnica delle Marche, 60126, Ancona, Italy.
Giada TorresiChemistry Interdisciplinary Project (ChIP), School of Pharmacy, University of Camerino, 62032, Camerino, Italy.
Valentina TarantinoDepartment of Clinical and Molecular Sciences, Università Politecnica delle Marche, 60126, Ancona, Italy.
Gaia GoteriDepartment of Pathological Anatomy, AOU delle Marche, Università Politecnica delle Marche, 60126, Ancona, Italy.
Alessandra FilosaDepartment of Pathological Anatomy, AOU delle Marche, Università Politecnica delle Marche, 60126, Ancona, Italy.
Francesca BarbisanDepartment of Pathological Anatomy, AOU delle Marche, Università Politecnica delle Marche, 60126, Ancona, Italy.
Elisa BartoliDepartment of Pathological Anatomy, AOU delle Marche, Università Politecnica delle Marche, 60126, Ancona, Italy.
Francesca BianchiDepartment of Clinical and Molecular Sciences, Università Politecnica delle Marche, 60126, Ancona, Italy.
Natalia ChiodiDepartment of Clinical and Molecular Sciences, Università Politecnica delle Marche, 60126, Ancona, Italy.
Elisa AmbrosiniDepartment of Clinical and Molecular Sciences, Università Politecnica delle Marche, 60126, Ancona, Italy.
Giulia RicciDepartment of Medical Oncology, AOU delle Marche, 60126, Ancona, Italy.
Alessandra LucarelliDepartment of Medical Oncology, AOU delle Marche, 60126, Ancona, Italy.
Michela BurattiniDepartment of Medical Oncology, AOU delle Marche, 60126, Ancona, Italy.
Alice BiagioniDepartment of Clinical and Molecular Sciences, Università Politecnica delle Marche, 60126, Ancona, Italy.
Sara ChiariottiDepartment of Clinical and Molecular Sciences, Università Politecnica delle Marche, 60126, Ancona, Italy.
Simona MagiDepartment of Biomedical Sciences and Public Health, Pharmacology, Università Politecnica delle Marche, 60126, Ancona, Italy.
Giulia MentrastiDepartment of Medical Oncology, AOU delle Marche, 60126, Ancona, Italy.
Francesca MorgeseDepartment of Medical Oncology, AOU delle Marche, 60126, Ancona, Italy.
Roberto PapaQuality, Risk Management and Health Technology Innovation Unit, Department of Staff, AOU delle Marche, 60126, Ancona, Italy.
Riccardo PetrelliChemistry Interdisciplinary Project (ChIP), School of Pharmacy, University of Camerino, 62032, Camerino, Italy.
Rossana BerardiDepartment of Clinical and Molecular Sciences, Università Politecnica delle Marche, 60126, Ancona, Italy. r.berardi@staff.univpm.it.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionCancer incidence is rising in Italy, making it harder for researchers to search for innovative and comprehensive treatment strategies. The advancement of precision medicine, the hunt for molecular targets, and the development of drugs that may operate on a specific target have all become increasingly important aspects of the oncological treatment strategy in recent years. The aim of this study is to analyze the activity and performance of the Oncology and Research Center of the Marche Region (CORM) and its Molecular Tumor Board (MTB) in implementing precision medicine to improve cancer treatment.

methodsCORM was established to provide multidisciplinary diagnostic and therapeutic services, promoting early diagnosis, innovative treatments, and continuous patients support. The MTB, including various specialists, facilitates the interpretation of genomic profiles to identify targeted therapies.

resultsFrom June 2021 to May 2024, 118 patients were evaluated at the MTB of the Marche Region, with 77 undergoing molecular profiling. This study highlights the efficacy of the MTB in selecting appropriate molecular tests, interpreting results, and recommending personalized treatment strategies, leading to improved patient outcomes.

conclusionChallenges such as the complexity of genomic data interpretation and the need for more computational tools to assist clinicians were also identified. Still, constant multidisciplinary collaboration between experts and the finest possible innovative technological support are required to achieve the best outcomes in cancer treatment.

Indexed as

Clinical oncologyMolecular tumor boardMTBNGSPrecision medicine

Identifiers

PMID39903442
PMCPMC11880486

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.