Regulation by Trace Amine-Associated Receptor 1 (TAAR1) of Dopaminergic-GABAergic Interaction in the Striatum: Effects of the Enhancer Drug (-)BPAP.

Laszlo G Harsing, Gábor Szénási, Balázs Fehér, Ildikó Miklya

Abstract read

In one paragraph

Article in Neurochemical research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

Transcriptomic Analysis ofBrain sciences · 2025
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Laszlo G HarsingDepartment of Pharmacology and Pharmacotherapy, Semmelweis University, Budapest, Hungary.

Gábor SzénásiInstitute of Translational Medicine, Semmelweis University, Budapest, Hungary.

Balázs FehérBudapest University of Technology and Economics, Budapest, Hungary.

Ildikó MiklyaDepartment of Pharmacology and Pharmacotherapy, Semmelweis University, Budapest, Hungary. miklya.ildiko@med.semmelweis-univ.hu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Although it is well documented that the striatal GABAergic projection neurons receive excitatory and inhibitory dopaminergic innervation via D1 and D2 receptors, the trace amine-associated receptor 1 (TAAR1)-mediated regulation of this neural connection is much less studied. The presence of TAAR1 was originally detected in brain aminergic neurons, with recent evidence indicating its presence in striatal GABAergic neurons as well. The objective of the present study was to demonstrate the role of TAAR1 and signaling in dopaminergic-GABAergic interaction in the neural circuitry of the striatum. Besides trace amines, which are considered natural ligands for TAAR1, series of different exogenous drugs were identified to act on this receptor. Using the dopaminergic activity enhancer compound (-)BPAP ((-)-1-(benzofuran-2-yl)-2-propylaminopentane HCl), a potential agonist for TAAR1, we have found that it increased the electrical stimulation-induced [

Indexed as

BenzofuransCorpus StriatumDopamineGABAergic Neuronsgamma-Aminobutyric AcidReceptors, G-Protein-CoupledAnimalsDose-Response Relationship, DrugMaleRatsRats, Sprague-DawleyRats, WistarTrace Amine-Associated ReceptorsBenzofuransDopaminegamma-Aminobutyric AcidReceptors, G-Protein-CoupledTrace Amine-Associated Receptors[3H]Dopamine and [3H]GABA release(-)BPAPDopaminergic activity enhancer effectRat striatumTrace amines / Trace amine-associated receptor 1

Identifiers

PMID39903411

DOI10.1007/s11064-025-04337-7

PMCPMC11794408

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.