Evidence map›Paper›PMID 39903410›Full record

ArticleBrain imaging and behavior2025

Elevated vascular endothelial growth factor a is associated with disruption of default network connectivity in older adults.

Arunima Kapoor, Jung Yun Jang, Allison C Engstrom, Trevor Lohman, Shubir Dutt, John Paul M Alitin, Isabel J Sible, Anisa Marshall, Fatemah Shenasa, Aimee Gaubert and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain imaging and behavior, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Arunima KapoorDepartment of Psychological Science, University of California, Irvine, Irvine, CA, USA.
Jung Yun JangInstitute for Memory Impairments and Neurological Disorders, University of California, Irvine, Irvine, CA, USA.
Allison C EngstromDepartment of Psychological Science, University of California, Irvine, Irvine, CA, USA.
Trevor LohmanLeonard Davis School of Gerontology, University of Southern California, 3715 McClintock Avenue, Los Angeles, CA, 90089, USA.
Shubir DuttDepartment of Neurology, Weill Institute for Neurosciences, Memory and Aging Center, University of California, San Francisco, San Francisco, CA, USA.
John Paul M AlitinLeonard Davis School of Gerontology, University of Southern California, 3715 McClintock Avenue, Los Angeles, CA, 90089, USA.
Isabel J SibleDepartment of Psychology, University of Southern California, Los Angeles, CA, USA.
Anisa MarshallDepartment of Psychology, University of Southern California, Los Angeles, CA, USA.
Fatemah ShenasaDepartment of Psychological Science, University of California, Irvine, Irvine, CA, USA.
Aimee GaubertLeonard Davis School of Gerontology, University of Southern California, 3715 McClintock Avenue, Los Angeles, CA, 90089, USA.
Amy NguyenLeonard Davis School of Gerontology, University of Southern California, 3715 McClintock Avenue, Los Angeles, CA, 90089, USA.
David Robert BradfordCenter for Innovations in Brain Science, Department of Pharmacology, University of Arizona, Tucson, AZ, USA.
Kathleen RodgersCenter for Innovations in Brain Science, Department of Pharmacology, University of Arizona, Tucson, AZ, USA.
S Duke HanLeonard Davis School of Gerontology, University of Southern California, 3715 McClintock Avenue, Los Angeles, CA, 90089, USA.
Daniel A NationLeonard Davis School of Gerontology, University of Southern California, 3715 McClintock Avenue, Los Angeles, CA, 90089, USA. danation@usc.edu.

Funding

Vascular Contributions to Dementia and Genetic Risk Factors for Alzheimer's DiseaseP01AG052350 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Daniel A Nation, ARTHUR W TOGA · 2016 to 2026
$28.4M
USCADRC Diversity Supplement PachicanoP30AG066530 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI HELENA Chang CHUI · 2020 to 2026
$27.8M
Locus Coeruleus Imaging Markers in Preclinical Alzheimers disease, Cerebrovascular Disease and Cognitive DeclineR01AG082073 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI BONDI, MARK W, MATHER, MARA · 2023 to 2025
$4.9M
Endothelial progenitor cells and neurovascular injury in the aging brainR01AG064228 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Daniel A Nation · 2019 to 2026
$4.5M
Cerebrovascular resistance in cognitive aging and Alzheimer's disease riskR01AG060049 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI NATION, DANIEL A · 2020 to 2023
$2.4M
NIA NIH HHS P01 AG052350NIA NIH HHS P30 AG066530NIA NIH HHS R01 AG060049NIA NIH HHS R01 AG064228NIA NIH HHS R01 AG082073
6 · The paper itself

Abstract

Vascular Endothelial Growth Factor A (VEGF-A) is an angiogenic signaling protein involved in the maintenance of the cerebral vasculature. No prior study has explored whether plasma VEGF-A levels may be associated with brain functional connectivity changes, such as disruption of the default mode network (DMN), which often precedes the development of cognitive changes in aging. Seventy-six independently living older adults (mean age = 70.3 years; SD = 7.5; 31.6% male) free of dementia or clinical stroke underwent venipuncture and brain MRI. Plasma was assayed for VEGF-A. Using resting state functional MRI, region of interest (ROI) to ROI connectivity and graph theory analysis were conducted to determine average connectivity and global efficiency between each of the following ROIs comprising the DMN: medial prefrontal cortex, lateral parietal cortex and precuneus cortex. Multiple linear regression analysis revealed a significant negative association between VEGF-A levels and DMN connectivity (B = - 0.14, 95% CI (-0.26, - 0.01), p =.038), accounting for age, sex, education, and vascular risk factors. Graph theory analysis similarly revealed that VEGF-A levels are associated with global efficiency of the entire network (B = - 0.18, p =.004). These findings suggest that VEGF-A may be elevated early in the progression of neurocognitive disorders. Whether higher levels of VEGF-A contribute to the pathogenesis of neurocognitive disorders or play a protective role in preserving cognitive function warrants further investigation. Clinical Trial Number: N/A; None.

Indexed as

AgingBrainDefault Mode NetworkNerve NetVascular Endothelial Growth Factor AAgedAged, 80 and overBrain MappingFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedNeural PathwaysVascular Endothelial Growth Factor AVEGFA protein, humanDefault network connectivityVascular endothelial growth factor A

Identifiers

PMID39903410
PMCPMC11978527

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.