Evidence map›Paper›PMID 39903404›Full record

ArticleMedical oncology (Northwood, London, England)2025

A comparative analysis of gallstones from gallbladder cancer patients and cholelithiasis patients unveiling the association between gallstones and gallbladder cancer.

Bhavna Sharma, Ratnakar Shukla, Anand Nagar, Nishith Ekka, Vinay Kumar Kapoor, Anu Behari, Shubha Rani Sharma

Abstract readComparative Study
PubMed Publisher
In one paragraph

Article in Medical oncology (Northwood, London, England), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

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1 citing paper in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Bhavna SharmaDepartment of Bioengineering and Biotechnology, Birla Institute of Technology, Mesra, Ranchi, India.
Ratnakar ShuklaSharda School of Allied Health Sciences, Greater Noida, India.
Anand NagarDepartment of Surgical Gastroenterology, Mahatma Gandhi Medical College and Hospital, Jaipur, India.
Nishith EkkaDepartment of Surgery, Rajendra Institute of Medical Sciences, Ranchi, India.
Vinay Kumar KapoorDepartment of Surgical Gastroenterology, Mahatma Gandhi Medical College and Hospital, Jaipur, India.
Anu BehariDepartment of Surgical Gastroenterology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India.
Shubha Rani SharmaDepartment of Bioengineering and Biotechnology, Birla Institute of Technology, Mesra, Ranchi, India. srsharma@bitmesra.ac.in.ORCID http://orcid.org/0000-0002-9201-3532

Funding

Institute Research fellowship of Birla Institute of Technology GO/ Estb/Ph.D/IRF/2019-20/6649
6 · The paper itself

Abstract

Gallstones (GS) are one of the most common gastrointestinal diseases. Till date medical cure for gallstones is not available. Unlike kidney stones, GS need cholecystectomy, i.e. surgical removal of the gallbladder (GB). GS are asymptomatic in most of the cases. They are the cause of GB inflammation that is chronic cholecystitis. GS have been supposed to be an important risk factor for causing gallbladder cancer (GBC). But the exact relationship between GS and GBC is not clear till date. In this study, we have compared the gallstones from cholelithiasis patients with those from patients with GBC. The size, volume and weight of these GS were comparatively analyzed. We have performed compositional as well as heavy metal analysis of the GS for both groups of patients by FTIR, FESEM and ICP-MS. The size and volume of gallstones from GBC patients was found to be on the higher side. We found that the GS from GBC patients were only of cholesterol type while those from cholelithiasis patients were mixed and pigment type. Heavy metals such as As, Pb, Fe were detected in higher concentration in GS from GBC patients. Thus, heavy metals detected in the gallstones could be regarded as the contributing factors to GBC. Further the mechanism of initiation of cancer by heavy metals in presence of cholesterol GS needs to be studied, so that novel strategies can be developed for the prevention of GBC.

Indexed as

CholelithiasisGallbladder NeoplasmsGallstonesAdultAgedFemaleHumansMaleMetals, HeavyMiddle AgedMetals, HeavyCholecystitisCholelithiasisCholesterolGallbladder cancerGallstonesHeavy metalsInflammation

Identifiers

PMID39903404

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.