Evidence map›Paper›PMID 39903398›Full record

ArticleMolecular diversity2025

1-Styryl-1,3-diketones in the synthesis of spiro[oxindole-3,2'-pyrrolidines] with notable anticancer activity.

Nikolay S Zimnitskiy, Vladislav Y Korotaev, Maria V Ulitko, Vyacheslav Y Sosnovskikh

Erratum issuedAbstract read
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In one paragraph

Article in Molecular diversity, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Nikolay S ZimnitskiyInstitute of Natural Sciences and Mathematics, Ural Federal University, Kuibyshev Str., 48, Yekaterinburg, 620002, Russia. n.s.zimnitsky@urfu.ru.ORCID http://orcid.org/0000-0002-1156-0922
Vladislav Y KorotaevInstitute of Natural Sciences and Mathematics, Ural Federal University, Kuibyshev Str., 48, Yekaterinburg, 620002, Russia. korotaev.vladislav@urfu.ru.ORCID http://orcid.org/0000-0002-7492-5116
Maria V UlitkoInstitute of Natural Sciences and Mathematics, Ural Federal University, Kuibyshev Str., 48, Yekaterinburg, 620002, Russia.ORCID http://orcid.org/0000-0003-3193-2903
Vyacheslav Y SosnovskikhInstitute of Natural Sciences and Mathematics, Ural Federal University, Kuibyshev Str., 48, Yekaterinburg, 620002, Russia.ORCID http://orcid.org/0000-0002-8956-0973

Funding

Ministry of Science and Higher Education of the Russian Federation FEUZ-2023-0016
6 · The paper itself

Abstract

A regio- and stereoselective method for the synthesis of spiro[indolin-3,2'-pyrrolidine]-2-ones based on the [3 + 2] cycloaddition of azomethine ylides, generated in situ from isatins and proteinogenic α-amino acids, and (E)-5-arylpent-4-ene-1,3-diones under reflux in methanol within 12 h in 28-91% yields has been developed. A number of representative examples of spiro[indolin-3,2'-pyrrolidine]-2-ones have been studied for cytotoxic activity against HeLa cervical cancer cell line and human dermal fibroblasts (HDF) by the MTT assay. Every investigated compound has shown cytotoxic activity against HeLa cells (IC

Indexed as

Antineoplastic AgentsIndolesKetonesPyrrolidinesSpiro CompoundsDrug Screening Assays, AntitumorFibroblastsHeLa CellsHumansMolecular StructureOxindolesStructure-Activity Relationship2-oxindoleAntineoplastic AgentsIndolesKetonesOxindolesPyrrolidinesSpiro Compounds[3 + 2] CycloadditionAzomethine ylidesCytotoxicity(E)-5-Arylpent-4-ene-1,3-dionesSpirooxindolesα-Amino acids

Identifiers

PMID39903398

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.