Evidence map›Paper›PMID 39903380›Full record

ArticleInternational urology and nephrology2025

Secular trends in cytomegalovirus (CMV) risk and outcomes: results from a 10-year longitudinal cohort study in adult kidney transplant recipients.

Amy Perry, Karim Soliman, Erika Andrade, Zaid Mesmar, Morgan Overstreet, Tibor Fulop, Isabel K Calimlim, Courtney Harris, David J Taber

Abstract read
PubMed Publisher
In one paragraph

Article in International urology and nephrology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Amy PerryMedical Services, Ralph H. Johnson VA Medical Center, 109 Bee Street, Charleston, SC, 29401, USA. perrya219@hotmail.com.ORCID http://orcid.org/0009-0001-3808-4751
Karim SolimanMedical Services, Ralph H. Johnson VA Medical Center, 109 Bee Street, Charleston, SC, 29401, USA.ORCID http://orcid.org/0000-0002-0960-2644
Erika AndradeCollege of Medicine, Medical University of South Carolina, Charleston, SC, USA.
Zaid MesmarDepartment of Surgery, Medical University of South Carolina, Charleston, SC, USA.ORCID http://orcid.org/0000-0001-6218-5475
Morgan OverstreetDepartment of Surgery, Medical University of South Carolina, Charleston, SC, USA.
Tibor FulopMedical Services, Ralph H. Johnson VA Medical Center, 109 Bee Street, Charleston, SC, 29401, USA.ORCID http://orcid.org/0000-0002-3346-7040
Isabel K CalimlimDepartment of Surgery, Medical University of South Carolina, Charleston, SC, USA.ORCID http://orcid.org/0009-0005-8751-6468
Courtney HarrisDivision of Infectious Diseases, Medical University of South Carolina, Charleston, SC, USA.ORCID http://orcid.org/0000-0003-4611-0670
David J TaberDepartment of Surgery, Medical University of South Carolina, Charleston, SC, USA.ORCID http://orcid.org/0000-0001-7273-4589

Funding

Merck 61223
6 · The paper itself

Abstract

backgroundThe goal of this study was to determine the secular trends in the incidence of CMV sero-mismatch (D+/R -) and if these trends meaningfully impact clinical outcomes.

methodsThis was a single-center longitudinal cohort study in adult kidney recipients transplanted between Jan 2012 and June 2021 with follow-up through June 2022. Baseline and follow-up data were collected. Univariate and multivariate statistics were used to analyze the data.

results2,392 kidney transplants were performed during the study period; 132 patients did not meet inclusion criteria. The mean age was 52 years, 41% were female, 57% were black, and 19% were CMV D + /R -. The odds of being CMV high-risk increased by 6% each year (OR 1.06, 1.02-1.10 p = 0.003); 48% of the variability associated with CMV serostatus was explained by transplant year (R

conclusionThe CMV D + /R - serostatus remains the single most important risk factor for CMV infection, disease, resistance, refractory infection, and late CMV, which appears to be increasing in magnitude.

Indexed as

Cytomegalovirus InfectionsKidney TransplantationPostoperative ComplicationsAdultCohort StudiesFemaleHumansIncidenceLongitudinal StudiesMaleMiddle AgedRisk FactorsTime FactorsCMVCytomegalovirus infectionsFollow-up studiesKidneyKidney transplantationLongitudinal studiesOpportunistic infectionsRisk factorsSecularTransplant

Identifiers

PMID39903380

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.