ArticleMolecular biology reports2025
In silico investigation and expression analysis of two-component regulatory systems in Proteus mirabilis.
Article in Molecular biology reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundProteus mirabilis (P. mirabilis), a Gram-negative bacterium from the Morganellaceae family, exists in various habitats, ranging from natural environmental sources to animal and human host. Two-component systems (TCSs) are involved in sensing various types of stimuli present in the environment, including antimicrobial chemotherapeutics. Moreover, TCSs regulate bacterial virulence. The 16 sets of genes encoding TCSs proteins have been identified in genome of P. mirabilis HI4320 reference strain, but their role remains understudied. METHODS AND
resultsIn the presented work, a comparative in silico analysis of TCSs proteins encoded by the genome sequences of P. mirabilis strains obtained from public databases was performed. Additionally, the expression of genes encoding regulatory proteins in response to polymyxin B and H
conclusionsPresented study shed light on the role of TCSs in P. mirabilis. Further deepen research in this area might provide more effective means for controlling P. mirabilis infections.
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