Evidence map›Paper›PMID 39903307›Full record

ReviewLasers in medical science2025

Photobiomodulation of gut microbiota with low-level laser therapy: a light for treating neuroinflammation.

Larissa Espindola da Silva, Daniel Fernandes Martins, Mariana Pacheco de Oliveira, Mariella Reinol Stenier, Bruna Barros Fernandes, Stefanny da Silva Willemann, Gabriela de Souza, Willians Fernando Vieira, Andrew Hewitson, Francisco J Cidral-Filho and 1 more

Abstract readReview
PubMed Publisher
In one paragraph

Review in Lasers in medical science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Larissa Espindola da SilvaLaboratory of Neurobiology of Inflammatory and Metabolic Processes (Neuroimet), Graduate Program in Health Sciences, University of Southern Santa Catarina, Tubarão, Brazil. larissa_espindola@outlook.com.
Daniel Fernandes MartinsExperimental Neuroscience Laboratory (LaNEx), Graduate Program in Health Sciences, University of Southern Santa Catarina, Palhoça, Brazil.
Mariana Pacheco de OliveiraLaboratory of Neurobiology of Inflammatory and Metabolic Processes (Neuroimet), Graduate Program in Health Sciences, University of Southern Santa Catarina, Tubarão, Brazil.
Mariella Reinol StenierLaboratory of Neurobiology of Inflammatory and Metabolic Processes (Neuroimet), Graduate Program in Health Sciences, University of Southern Santa Catarina, Tubarão, Brazil.
Bruna Barros FernandesLaboratory of Neurobiology of Inflammatory and Metabolic Processes (Neuroimet), Graduate Program in Health Sciences, University of Southern Santa Catarina, Tubarão, Brazil.
Stefanny da Silva WillemannLaboratory of Neurobiology of Inflammatory and Metabolic Processes (Neuroimet), Graduate Program in Health Sciences, University of Southern Santa Catarina, Tubarão, Brazil.
Gabriela de SouzaExperimental Neuroscience Laboratory (LaNEx), Graduate Program in Health Sciences, University of Southern Santa Catarina, Palhoça, Brazil.
Willians Fernando VieiraDepartment of Anatomy, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.
Andrew HewitsonAvant Wellness Systems, Thousand Oaks, USA.
Francisco J Cidral-FilhoExperimental Neuroscience Laboratory (LaNEx), Graduate Program in Health Sciences, University of Southern Santa Catarina, Palhoça, Brazil.
Gislaine Tezza RezinLaboratory of Neurobiology of Inflammatory and Metabolic Processes (Neuroimet), Graduate Program in Health Sciences, University of Southern Santa Catarina, Tubarão, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The gut microbiota is known to interact with various organs in the body, including the central nervous system, through the gut-brain axis. Intestinal dysbiosis can lead to increased peripheral inflammation and, consequently, affect the brain, resulting in neuroinflammation. Photobiomodulation (PBM) has demonstrated positive regulatory effects on the imbalance of certain body functions, including pain, inflammation, immunity, wound healing, and gut microbiota dysbiosis. Therefore, PBM at the intestinal level could help improve intestinal dysbiosis and reestablish cerebral homeostasis. In this context, this study aimed to conduct a narrative review of the literature on the effects of PBM at the intestinal level on intestinal dysbiosis and neuroinflammation. Overall, the findings highlight that PBM modulates the gut microbiota, suggesting it could serve as a therapy for neurological conditions affecting the gut-brain axis. Future research should focus on further elucidating the molecular mechanisms underlying this therapy.

Indexed as

DysbiosisGastrointestinal MicrobiomeLow-Level Light TherapyNeuroinflammatory DiseasesAnimalsHumansGut microbiotaLaser therapyNeuroinflammationPhotobiomodulation

Identifiers

PMID39903307

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.