Evidence map›Paper›PMID 39903107›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2025

Uncovering the hidden RNA virus diversity in Lake Nam Co: Evolutionary insights from an extreme high-altitude environment.

Lilin Wu, Yongqin Liu, Wenqing Shi, Tianyi Chang, Pengfei Liu, Keshao Liu, Yong He, Zhaorong Li, Mang Shi, Nianzhi Jiao and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Lilin Wu *Department of Marine Biology and Technology, College of Ocean and Earth Sciences and State Key Laboratory of Marine Environmental Science, Xiamen University, Xiamen 361005, China.ORCID 0009-0002-8864-526X
Yongqin Liu *Center for the Pan-Third Pole Environment, Lanzhou University, Lanzhou 730000, China.
Wenqing ShiDepartment of Marine Biology and Technology, College of Ocean and Earth Sciences and State Key Laboratory of Marine Environmental Science, Xiamen University, Xiamen 361005, China.
Tianyi ChangDepartment of Marine Biology and Technology, College of Ocean and Earth Sciences and State Key Laboratory of Marine Environmental Science, Xiamen University, Xiamen 361005, China.
Pengfei LiuCenter for the Pan-Third Pole Environment, Lanzhou University, Lanzhou 730000, China.ORCID 0000-0003-1003-2025
Keshao LiuState Key Laboratory of Tibetan Plateau Earth System, Resources and Environment, Institute of Tibetan Plateau Research, Chinese Academy of Sciences, Beijing 100101, China.
Yong HeAlibaba Cloud Intelligence, Alibaba Group, Hangzhou 310013, China.
Zhaorong LiAlibaba Cloud Intelligence, Alibaba Group, Hangzhou 310013, China.
Mang ShiCentre for Infection and Immunity Study, School of Medicine (Shenzhen), Shenzhen Campus of Sun Yat-sen University, Sun Yat-sen University, Shenzhen 518107, China.ORCID 0000-0002-6154-4437
Nianzhi JiaoDepartment of Marine Biology and Technology, College of Ocean and Earth Sciences and State Key Laboratory of Marine Environmental Science, Xiamen University, Xiamen 361005, China.
Andrew S LangDepartment of Biology, Memorial University of Newfoundland, St. John's, NL A1C 5S7, Canada.
Xiyang DongKey Laboratory of Marine Genetic Resources, Third Institute of Oceanography, Ministry of Natural Resources, Xiamen 361005, China.ORCID 0000-0002-9224-5923
Qiang ZhengDepartment of Marine Biology and Technology, College of Ocean and Earth Sciences and State Key Laboratory of Marine Environmental Science, Xiamen University, Xiamen 361005, China.

Funding

MOST | National Key Research and Development Program of China (NKPs) 2021QZKK0102MOST | National Natural Science Foundation of China (NSFC) 42188102 42222604 92351303 and 92251306
6 · The paper itself

Abstract

Alpine lakes, characterized by isolation, low temperatures, oligotrophic conditions, and intense ultraviolet radiation, remain a poorly explored ecosystem for RNA viruses. Here, we present the first comprehensive metatranscriptomic study of RNA viruses in Lake Nam Co, a high-altitude alkaline saline lake on the Tibetan Plateau. Using a combination of sequence- and structure-based homology searches, we identified 742 RNA virus species, including 383 novel genus-level groups and 84 novel family-level groups exclusively found in Lake Nam Co. These findings significantly expand the known diversity of the

Indexed as

LakesRNA VirusesAltitudeEvolution, MolecularGenetic VariationGenome, ViralPhylogenyRNA, ViralTibetRNA, ViralAlpine lakesLake Nam CoRNA-dependent RNA polymeraseRNA viruses

Identifiers

PMID39903107
PMCPMC11831205

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.