ArticleJournal of virology2025
Targeting Ikaros and Aiolos with pomalidomide fails to reactivate or induce apoptosis of the latent HIV reservoir.
Rachel D Pascoe, Youry Kim, Ajantha Rhodes, Jesslyn Ong, Carolin Tumpach, Celine Gubser, J Judy Chang, James H McMahon, Sharon R Lewin, Thomas A Rasmussen
Abstract read
In one paragraphArticle in Journal of virology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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2 · The registryThe trial behind it
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
10 authors.
Rachel D PascoeDepartment of Microbiology and Immunology, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia.ORCID 0000-0001-7707-1972 Youry KimDepartment of Infectious Diseases, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia.
Ajantha RhodesDepartment of Infectious Diseases, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia.
Jesslyn OngDepartment of Infectious Diseases, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia.
Carolin TumpachDepartment of Infectious Diseases, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia.
Celine GubserDepartment of Infectious Diseases, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia.
J Judy ChangDepartment of Infectious Diseases, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia.
James H McMahonDepartment of Infectious Diseases, Alfred Hospital and Monash University, Melbourne, Victoria, Australia.
Sharon R Lewin *Department of Infectious Diseases, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia.ORCID 0000-0002-0330-8241 Thomas A Rasmussen *Department of Infectious Diseases, Aarhus University Hospital, Aarhus, Denmark.
Funding
DHAC | National Health and Medical Research Council (NHMRC) Program
6 · The paper itselfAbstract
HIV persists in people living with HIV (PLHIV) on antiretroviral therapy (ART) in long-lived and proliferating latently infected CD4+ T cells that selectively express pro-survival proteins, including the zinc finger proteins, Ikaros and Aiolos. In this study, we investigated whether pomalidomide, an immunomodulatory agent that induces degradation of Ikaros and Aiolos, could increase the death of HIV-infected cells and/or reverse HIV latency. Using an
Indexed as
ApoptosisHIV-1HIV InfectionsIkaros Transcription FactorThalidomideVirus LatencyAdaptor Proteins, Signal TransducingCD4-Positive T-LymphocytesHumansKiller Cells, NaturalProto-Oncogene Proteins c-bcl-2Ubiquitin-Protein LigasesVirus ActivationAdaptor Proteins, Signal TransducingCRBN protein, humanIkaros Transcription FactorIKZF1 protein, humanIKZF3 protein, humanpomalidomideProto-Oncogene Proteins c-bcl-2ThalidomideUbiquitin-Protein LigasesapoptosisHIVlatency
Identifiers
PMID39902962
PMCPMC11915836
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