Evidence map›Paper›PMID 39902803›Full record

ArticleeLife2025

Intergenerational transport of double-stranded RNA in

Nathan M Shugarts Devanapally, Aishwarya Sathya, Andrew L Yi, Winnie M Chan, Julia A Marre, Antony M Jose

Abstract read
In one paragraph

Article in eLife, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Nathan M Shugarts DevanapallyDepartment of Cell Biology and Molecular Genetics, University of Maryland, College Park, United States.ORCID https://orcid.org/0000-0003-4140-7010
Aishwarya SathyaDepartment of Cell Biology and Molecular Genetics, University of Maryland, College Park, United States.ORCID https://orcid.org/0000-0001-6128-0040
Andrew L YiDepartment of Cell Biology and Molecular Genetics, University of Maryland, College Park, United States.
Winnie M ChanDepartment of Cell Biology and Molecular Genetics, University of Maryland, College Park, United States.
Julia A MarreDepartment of Cell Biology and Molecular Genetics, University of Maryland, College Park, United States.
Antony M JoseDepartment of Cell Biology and Molecular Genetics, University of Maryland, College Park, United States.ORCID https://orcid.org/0000-0003-1405-0618

Funding

Transgenerational gene silencing by extracellular RNAR01GM124356 · NIGMS · UNIV OF MARYLAND, COLLEGE PARK · PI JOSE, ANTONY MERLIN · 2018 to 2025
$2.8M
Training Program in Cell & Molecular BiologyT32GM080201 · NIGMS · UNIV OF MARYLAND, COLLEGE PARK · PI DELWICHE, CHARLES F · 2009 to 2019
$1.6M
Movement of RNA between animal cellsR01GM111457 · NIGMS · UNIV OF MARYLAND, COLLEGE PARK · PI JOSE, ANTONY MERLIN · 2014 to 2018
$1.4M
Zeiss LSM 880 Airyscan Fast Laser Scanning ConfocalS10OD025223 · OD · UNIV OF MARYLAND, COLLEGE PARK · PI BEAVEN, AMY · 2019 to 2019
$557k
National Science Foundation 2120895NIGMS NIH HHS R01 GM111457NIGMS NIH HHS R01GM111457NIGMS NIH HHS R01 GM124356NIGMS NIH HHS R01GM124356NIGMS NIH HHS T32 GM080201NIH HHS S10 OD025223University of Maryland UMD CMNS Dean's Matching Award for "Training Program in Cell and Molecular Biology" T32GM080201
6 · The paper itself

Abstract

RNAs in circulation carry sequence-specific regulatory information between cells in plant, animal, and host-pathogen systems. Such RNA can cross generational boundaries, as evidenced by somatic double-stranded RNA (dsRNA) in the nematode

Indexed as

Caenorhabditis elegansCaenorhabditis elegans ProteinsEpigenesis, GeneticRNA, Double-StrandedAnimalsMembrane ProteinsRetroelementsRNA InterferenceCaenorhabditis elegans ProteinsMembrane ProteinsRetroelementsRNA, Double-StrandedSID-1 protein, C elegansC. elegansgene expressiongeneticsgenomicsgernmlineheritable silencingRNAistochastictransport

Identifiers

PMID39902803
PMCPMC11793870

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.