ArticleAnalytical methods : advancing methods and applications2025
A rapid method for the determination of methylmercury and inorganic mercury species in whole blood by liquid chromatography with detection using vapor generation ICP-MS/MS.
Article in Analytical methods : advancing methods and applications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2 citing papers in PubMed.
- Human Mercury Biomonitoring Under the Minamata Convention: Blood, Urine, Hair, and Tissue Biomarkers (2000-2026).Biological trace element research · 2026Review
- Eco-friendly silver nanoparticle-based dual sensors for environmental toxicants: HgRSC advances · 2026Article
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Abstract
Speciation methods provide a more detailed picture regarding human exposure to toxic metals/metalloids and their effects on human health. The toxicity of methylmercury (MeHg) differs considerably from inorganic mercury (iHg), such that their separation and quantification in whole blood is helpful in identifying sources and possible pathways of exposure. Liquid chromatography (LC) has several advantages over gas chromatography (GC) for the separation of iHg from MeHg due to the former's compatibility with uptake rates of common nebulizer systems used with ICP-MS and the latter's requirement for a derivatization step to produce gaseous Hg species for an effective separation. Here we report an improved method that was developed to separate and quantify MeHg and iHg species in whole blood using isocratic LC elution with determination by vapor generation (VG) coupled with ICP-MS/MS. Chromatographic separation of MeHg and iHg is achieved in ∼4 minutes on a C8 reversed phase column. In those rare cases where there may be human exposure to ethylmercury (EtHg), or where a certified reference material (CRM) is known to contain EtHg (
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