Evidence map›Paper›PMID 39902740›Full record

ArticleJournal of the American Chemical Society2025

Spatial Control of CAR T Cell Activation Using Tumor-Homing Polymers.

Clinton M Heinze, Trey J Pichon, Abe Y Wu, Michael Baldwin, James Matthaei, Kefan Song, Meilyn Sylvestre, Joshua Gustafson, Nathan J White, Michael C Jensen and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the American Chemical Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. From Bench to Bedside: Emerging Paradigms in CAR-T Cell Therapy for Solid Malignancies.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Clinton M HeinzeDepartment of Bioengineering and Molecular Engineering and Sciences Institute, University of Washington, 3720 15th Avenue NE, Box 355061, Seattle, Washington 98195, United States.
Trey J PichonDepartment of Bioengineering and Molecular Engineering and Sciences Institute, University of Washington, 3720 15th Avenue NE, Box 355061, Seattle, Washington 98195, United States.
Abe Y WuDepartment of Bioengineering and Molecular Engineering and Sciences Institute, University of Washington, 3720 15th Avenue NE, Box 355061, Seattle, Washington 98195, United States.ORCID 0009-0007-8815-6091
Michael BaldwinSeattle Children's Therapeutics, Seattle Children's Research Institute, 1920 Terry Ave, Seattle, Washington 98101, United States.
James MatthaeiSeattle Children's Therapeutics, Seattle Children's Research Institute, 1920 Terry Ave, Seattle, Washington 98101, United States.
Kefan SongDepartment of Bioengineering and Molecular Engineering and Sciences Institute, University of Washington, 3720 15th Avenue NE, Box 355061, Seattle, Washington 98195, United States.ORCID 0000-0002-8925-0094
Meilyn SylvestreDepartment of Bioengineering and Molecular Engineering and Sciences Institute, University of Washington, 3720 15th Avenue NE, Box 355061, Seattle, Washington 98195, United States.ORCID 0000-0002-4162-9388
Joshua GustafsonSeattle Children's Therapeutics, Seattle Children's Research Institute, 1920 Terry Ave, Seattle, Washington 98101, United States.
Nathan J WhiteResuscitation Engineering Science Unit (RESCU), Harborview Research and Training Building, Seattle, Washington 98104, United States.
Michael C JensenSeattle Children's Therapeutics, Seattle Children's Research Institute, 1920 Terry Ave, Seattle, Washington 98101, United States.
Suzie H PunDepartment of Bioengineering and Molecular Engineering and Sciences Institute, University of Washington, 3720 15th Avenue NE, Box 355061, Seattle, Washington 98195, United States.ORCID 0000-0003-1443-4996

Funding

An integrated polymeric carrier for subunit cancer vaccinesR01CA257563 · NCI · UNIVERSITY OF WASHINGTON · PI PUN, SUZIE H., STAYTON, PATRICK S. · 2021 to 2025
$2.4M
Synthetic Hemostats for Trauma TreatmentR01HL139007 · NHLBI · UNIVERSITY OF WASHINGTON · PI PUN, SUZIE H., WHITE, NATHAN J · 2017 to 2020
$2.3M
Traceless, aptamer-based cell isolation for cell therapy applicationsR01EB034235 · NIBIB · UNIVERSITY OF WASHINGTON · PI Suzie H. Pun · 2023 to 2026
$1.4M
NCI NIH HHS R01 CA257563NHLBI NIH HHS R01 HL139007NIBIB NIH HHS R01 EB034235
6 · The paper itself

Abstract

CAR T cell therapies often lack specificity, leading to issues ranging from inadequate antigen targeting to off-tumor toxicities. To counter that lack of specificity, we expanded tumor targeting capabilities with universal CAR and spatially defined CAR T cell engagement with targets through a combination of synthetic biology and biomaterial approaches. We developed a novel framework, called "

Indexed as

Immunotherapy, AdoptivePolymersReceptors, Chimeric AntigenT-LymphocytesAnimalsCell Line, TumorHumansLymphocyte ActivationMicePolymersReceptors, Chimeric Antigen

Identifiers

PMID39902740
PMCPMC11995850

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.