Evidence map›Paper›PMID 39902565›Full record

ArticleMovement disorders clinical practice2025

Multimodality Brain Imaging Markers in Progressive Supranuclear Palsy Subtypes and Parkinson's Disease.

Kanchana Soman Pillai, Parvathy Rajeswari, Ravindra B Kamble, Shagos Gopalan Nair Santhamma, Manas Chacko, Vijay Jayakrishnan, Ranjini Ramachandran, Ayana Avarachan, Asha Kishore

Abstract read
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Article in Movement disorders clinical practice, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
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  5. The combination of theScientific reports · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Kanchana Soman PillaiParkinson and Movement Disorders Centre, Department of Neurology, Aster Medcity, Kochi, Kerala, India.ORCID https://orcid.org/0000-0003-4452-9144
Parvathy RajeswariParkinson and Movement Disorders Centre, Department of Neurology, Aster Medcity, Kochi, Kerala, India.
Ravindra B KambleDepartment of Radiology, Aster CMI Hospital, Bengaluru, Karnataka, India.
Shagos Gopalan Nair SanthammaDepartment of Nuclear Medicine, Aster Medcity, Kochi, Kerala, India.
Manas ChackoParkinson and Movement Disorders Centre, Department of Neurology, Aster Medcity, Kochi, Kerala, India.ORCID https://orcid.org/0000-0003-0800-173X
Vijay JayakrishnanDepartment of Radiology, Aster Medcity, Kochi, Kerala, India.
Ranjini RamachandranDepartment of Radiology, Aster Medcity, Kochi, Kerala, India.
Ayana AvarachanParkinson and Movement Disorders Centre, Department of Neurology, Aster Medcity, Kochi, Kerala, India.
Asha KishoreParkinson and Movement Disorders Centre, Department of Neurology, Aster Medcity, Kochi, Kerala, India.ORCID https://orcid.org/0000-0003-3292-1544

Funding

Aster Medcity Intramural research fund IMRS030
6 · The paper itself

Abstract

backgroundThe new classification of progressive supranuclear palsy (PSP) subtypes necessitates identifying radiological biomarkers to support the clinical diagnosis.

objectiveThe goal was to test if magnetic resonance imaging (MRI) morphometry, diffusion tensor imaging (DTI), susceptibility-weighted imaging (SWI), or [18F]fluorodeoxyglucose (

methodsMidbrain/pons (M/P) area ratio, middle/superior cerebellar peduncle (MCP/SCP) width ratio, magnetic resonance parkinsonism indices (MRPI and MRPI2) and midbrain antero-posterior (AP) diameter were measured. Region of interest-based DTI, SWI, and

resultsFour PSP subtypes (n = 85) and 24 PD were studied. MRI morphometry and DTI could differentiate PSP-Richardson syndrome (PSP-RS) from PSP-parkinsonism, PSP-postural instability, and PD (area under curve >0.7). SWI did not differentiate among PSP subtypes or PD.

conclusionsMRI morphometry and DTI differentiated PSP-RS from the other common PSP subtypes and PD and may be tested as a radiological marker of PSP-RS in larger studies.

Indexed as

BrainMultimodal ImagingParkinson DiseaseSupranuclear Palsy, ProgressiveAgedAged, 80 and overDiffusion Tensor ImagingFemaleFluorodeoxyglucose F18HumansMagnetic Resonance ImagingMaleMiddle AgedPositron-Emission TomographyFluorodeoxyglucose F18DTIFDG‐PETMRIprogressive supranuclear palsy subtypesSWI

Identifiers

PMID39902565
PMCPMC12070165

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