Evidence map›Paper›PMID 39902479›Full record

ArticleJournal of neurochemistry2025

Focused Ultrasound Modulates Dopamine in a Mesolimbic Reward Circuit.

Greatness Olaitan, Mallikarjunarao Ganesana, Andrew Strohman, Wendy J Lynch, Wynn Legon, B Jill Venton

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neurochemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Greatness OlaitanDepartment of Chemistry, University of Virginia, Charlottesville, Virginia, USA.ORCID 0000-0002-5633-8719
Mallikarjunarao GanesanaDepartment of Chemistry, University of Virginia, Charlottesville, Virginia, USA.ORCID 0000-0002-2834-023X
Andrew StrohmanGraduate Program in Translational Biology, Medicine, and Health, Virginia Polytechnic Institute and State University, Roanoke, Virginia, USA.ORCID 0000-0002-5547-8859
Wendy J LynchPsychiatry and Neurobehavioral Sciences, University of Virginia, Charlottesville, Virginia, USA.ORCID 0000-0003-4420-6150
Wynn LegonGraduate Program in Translational Biology, Medicine, and Health, Virginia Polytechnic Institute and State University, Roanoke, Virginia, USA.ORCID 0000-0002-8761-3496
B Jill VentonDepartment of Chemistry, University of Virginia, Charlottesville, Virginia, USA.ORCID 0000-0002-5096-9309

Funding

An investigation of low-intensity focused ultrasound for addictionR01DA052893 · NIDA · UNIVERSITY OF VIRGINIA · PI Wendy Jean Lynch, B. JILL VENTON · 2022 to 2026
$2.9M
NIDA NIH HHS R01 DA052893NIH HHS R01DA052893
6 · The paper itself

Abstract

Dopamine is a neurotransmitter that plays a significant role in reward and motivation. Dysfunction in the mesolimbic dopamine pathway has been linked to a variety of psychiatric disorders, including addiction. Low-intensity focused ultrasound (LIFU) has demonstrated effects on brain activity, but how LIFU affects dopamine neurotransmission is not known. Here, we applied three different intensities (6.5, 13, and 26 W/cm

Indexed as

DopamineLimbic SystemNucleus AccumbensPrefrontal CortexRewardUltrasonic WavesAnimalsMaleRatsRats, Sprague-DawleyDopamine

Identifiers

PMID39902479
PMCPMC11791541

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.