Evidence map›Paper›PMID 39902460›Full record

ArticleJournal of pharmaceutical analysis2025

Photoaffinity probe-enabled discovery of sennoside A reductase in

Yang Xu, Shujing Lv, Xiang Li, Chuanjia Zhai, Yulian Shi, Xuejiao Li, Zhiyang Feng, Gan Luo, Ying Wang, Xiaoyan Gao

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of pharmaceutical analysis, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Gut microbes · 2025
    Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yang XuSchool of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, 102488, China.
Shujing LvSchool of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, 102488, China.
Xiang LiSchool of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, 102488, China.
Chuanjia ZhaiSchool of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, 102488, China.
Yulian ShiSchool of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, 102488, China.
Xuejiao LiSchool of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, 102488, China.
Zhiyang FengSchool of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, 102488, China.
Gan LuoSchool of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, 102488, China.
Ying WangSchool of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, 102488, China.
Xiaoyan GaoSchool of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, 102488, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Sennoside A (SA), a typical prodrug, exerts its laxative effect only after its transformation into rheinanthrone catalyzed by gut microbial hydrolases and reductases. Hydrolases have been identified, but reductases remain unknown. By linking a photoreactive group to the SA scaffold, we synthesized a photoaffinity probe to covalently label SA reductases and identified SA reductases using activity-based protein profiling (ABPP). From lysates of an active strain,

Indexed as

Chemical biologyGut bacteriaPhotoaffinity labelingReductaseSennoside ASmall moleculeTransformation

Identifiers

PMID39902460
PMCPMC11788863

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.