Evidence map›Paper›PMID 39902448›Full record

ArticleJournal of maxillofacial and oral surgery2025

Role of Liquid Biopsy in Oral Premalignant and Malignant Lesions: Correlation with CD24 and CD44 Expression in Early Diagnosis of Oral Cancer.

O R Hemavathy, Muthusekhar Marimuthu Ramaswamy, C D Mohana Priya, Shrishty Bhardwaj

Abstract read
In one paragraph

Article in Journal of maxillofacial and oral surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

O R HemavathyDepartment of Oral and Maxillofacial Surgery, Saveetha Institute of Medical and Technical Sciences, Saveetha Dental College and Hospital, Chennai, India.ORCID 0000-0002-4895-3113
Muthusekhar Marimuthu RamaswamyDepartment of Oral and Maxillofacial Surgery, Saveetha Institute of Medical and Technical Sciences, Saveetha Dental College and Hospital, Chennai, India.
C D Mohana PriyaDepartment of Human Genetics, Sri Ramachandra Institute of Higher Education and Research, Chennai, India.
Shrishty BhardwajDepartment of Oral and Maxillofacial Surgery, Saveetha Institute of Medical and Technical Sciences, Saveetha Dental College and Hospital, Chennai, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aim: This study examines the levels of CD24 and CD44 expression in premalignant oral lesions (PMOL) and locally advanced oral squamous cell carcinoma (OSCC) in order to improve the early detection of the disease. We utilized RT-PCR techniques to examine the expression of two cell membrane proteins, CD24 and CD44, in blood and tissue samples. Methods: A quantitative real-time polymerase chain reaction was performed to evaluate the expression patterns of CD24 and CD44 in blood and tissue samples obtained from individuals with PMOL ( Results: CD24 was found to be increased in both tissue and blood groups. CD44 expression was higher in the tissue group in contrast to the blood group. The results for CD24 were statistically significant, with a Conclusion: In conjunction with histological characteristics and clinicopathological factors, CD24 serves as a dependable biomarker for the early diagnosis of OSCC.

Indexed as

BiomarkerBlood biopsyCD24CD44Circulating tumor cellsLiquid biopsyOral squamous cell carcinomaPrecancerous lesionsReal-time PCR

Identifiers

PMID39902448
PMCPMC11787126

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.