ReviewJournal of maxillofacial and oral surgery2025
Metronidazole for the Prophylaxis of Alveolar Osteitis: A Systematic Review and Meta-analysis.
Review in Journal of maxillofacial and oral surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Clinical Practices and Attitudes of Dental Practitioners in Managing Alveolar Osteitis: A Cross-Sectional Survey in Yemen.Clinical, cosmetic and investigational dentistry · 2026Article
- Patient with Inflammatory Bowel Disease in a Dental Office-Which Antibiotic to Choose?-Narrative Review.Journal of clinical medicine · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Aim: To assess, compare and evaluate the better effectiveness of metronidazole compared to conventional therapy for dry socket through a meta-analysis. Methods: Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines were used and registered in PROSPERO-CRD42023440597. Electronic databases were searched until April 2023 for studies evaluating the effectiveness of metronidazole compared to placebo and other conventional therapy and evaluating outcome in terms of reduction of incidence of dry socket, swelling and impact on healing. Quality assessment was evaluated using Cochrane risk of bias (ROB)-2 tool for randomized controlled trials (RCT) through its domains using RevMan software version 5.3. The risk ratio (RR) was used as summary statistic measure with random effect model ( Results: Twelve studies were included in review and eleven studies for meta-analysis. Quality assessment revealed a moderate to low ROB. It was observed that pooled estimate favoured metronidazole in reducing dry socket incidence-RR - 0.57 (95% CI - 0.24-1.33), reduction in swelling with RR - 0.62 (95% CI 0.12-3.25) and a greater impact on healing with RR - 0.25 (95% CI 0.12-0.52) were seen. Metronidazole was found to be superior compared to the placebo or conventional therapy. Funnel plot did reveal the presence of heterogeneity indicating the presence of publication bias. Clinical significance: Since, dry socket is the most common complication following third molar surgery, it is important for a clinician to take adequate precautions and consider regimes that can aid in reducing this incidence.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.