SynthesisPeerJ2025
Effect of exercise intervention on health-related quality of life in middle-aged and older people with osteoporosis: a systematic review and meta-analysis.
Synthesis in PeerJ, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Health-related quality of life instruments for older persons with osteoporosis: a WHO-BOHEG systematic review of measurement properties for use in clinical trials and routine practice.Age and ageing · 2026Pooled it
- Pooled it
- Physical activity levels and quality of life in osteoporosis patients.Frontiers in sports and active living · 2026Article
- Association between depression and osteoporosis in a population of cancer survivors: results from the NHANES 2005-2020.Frontiers in medicine · 2025Article
- Recent advances in the mechanisms and rehabilitation strategies of exercise interventions for osteoporosis in older adult women.Frontiers in physiology · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Osteoporosis is a common condition affecting middle-aged and older people, posing a serious threat to their health-related quality of life (HRQOL). In recent years, multiple studies have investigated the impact of exercise interventions on HRQOL in middle-aged and older individuals with osteoporosis, but the conclusions have been inconsistent. The aim of this study was to determine the true significance of exercise interventions on HRQOL in middle-aged and older individuals with osteoporosis and to identify optimal exercise prescriptions. Methods: Six databases were searched for RCTs on the impact of exercise interventions on HRQOL in middle-aged and older individuals with osteoporosis. The methodological quality of the study was evaluated with Cochrane risk assessment tool. The effect size pooling, heterogeneity testing, and publication bias were analyzed using Review Manager 5.4 software. Result: A total of 14 RCTs involving 1,214 participants were included, published between 2007 and 2022. The pooled results demonstrated that exercise interventions significantly improved general HRQOL (SMD = 0.79, 95% CI [0.34-1.24], Conclusion: Exercise interventions improved HRQOL in middle-aged and older individuals with osteoporosis. Resistance training has shown greater benefits than mixed exercises. The optimal frequency is at least three per week, yielding the greatest improvement. Exercise interventions lasting 13-24 weeks had the most pronounced effect compared to other durations. Registration: PROSPERO (No. CRD42023438771).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.