Evidence map›Paper›PMID 39902269›Full record

ArticleERJ open research2025

Biological correlates of radiological features of systemic sclerosis interstitial lung disease.

Elizabeth R Volkmann, Donald P Tashkin, Mei Leng, Grace Hyun J Kim, Jonathan Goldin, Airi Harui, Michael D Roth

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ERJ open research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Elizabeth R VolkmannDepartment of Medicine, University of California, Los Angeles, David Geffen School of Medicine, Los Angeles, CA, USA.
Donald P TashkinDepartment of Medicine, University of California, Los Angeles, David Geffen School of Medicine, Los Angeles, CA, USA.
Mei LengDepartment of Medicine, University of California, Los Angeles, David Geffen School of Medicine, Los Angeles, CA, USA.
Grace Hyun J KimDepartment of Radiology, University of California, Los Angeles, David Geffen School of Medicine, Los Angeles, CA, USA.ORCID https://orcid.org/0000-0003-1225-3489
Jonathan GoldinDepartment of Radiology, University of California, Los Angeles, David Geffen School of Medicine, Los Angeles, CA, USA.
Airi HaruiDepartment of Medicine, University of California, Los Angeles, David Geffen School of Medicine, Los Angeles, CA, USA.
Michael D RothDepartment of Medicine, University of California, Los Angeles, David Geffen School of Medicine, Los Angeles, CA, USA.

Funding

MOCSLID-DCCR01HL089901 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ELASHOFF, ROBERT M · 2008 to 2012
$9.1M
MOCSLID-CCCR01HL089758 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI TASHKIN, DONALD P · 2008 to 2012
$2.0M
CYTOKINES AS PREDICTORS OF DISEASE PROGRESSION IN SCLERODERMA LUNG DISEASER01AR055075 · NIAMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ROTH, MICHAEL D · 2006 to 2009
$1.3M
Identifying predictors of treatment response in systemic sclerosis-related interstitial lung diseaseK23HL150237 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI VOLKMANN, ELIZABETH R · 2020 to 2024
$910k
NHLBI NIH HHS K23 HL150237NHLBI NIH HHS R01 HL089758NHLBI NIH HHS R01 HL089901NIAMS NIH HHS R01 AR055075
6 · The paper itself

Abstract

Background and objectives: The extent and pattern of radiological features ( Methods: 68 proteins were measured in bronchoalveolar lavage (BAL) fluid from 103 SSc-ILD participants in Scleroderma Lung Study I. Quantitative image analysis calculated the extent of fibrosis (QLF) and ground-glass opacity (QGG) from concurrent high-resolution computed tomography (HRCT) scans. The relationship between BAL proteins and quantitative HRCT scores was assessed by univariate and multivariate analyses. Results: QLF scores correlated weakly with the extent of QGG, suggesting two distinct processes. In a univariate analysis, 25 proteins from several biological pathways correlated with QLF scores, including profibrotic factors, tissue remodelling proteins, proteins involved in monocyte/macrophage migration and activation, and proteins linked to inflammation and immune regulation. In contrast, QGG scores correlated with only six proteins, of which four were unique and related to granulocyte activation, mobilisation of bone marrow mesenchymal stem cells and activation of T-cells, B-cells, macrophages and eosinophils. In the multivariate models, interleukin-4, CCL7, receptor activator of nuclear factor-κB and tumour necrosis factor-α were independently associated with QLF, whereas interferon-γ was independently associated with QGG. Interpretation: QLF and QGG represent distinct radiological features of SSc-ILD, a conclusion reinforced by the presence of different biological pathways present within BAL fluid that associate with each. The identified proteins and related biological pathways may represent important therapeutic targets.

Identifiers

PMID39902269
PMCPMC11788817

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.