Evidence map›Paper›PMID 39902184›Full record

ArticleFrontiers in cellular and infection microbiology2024

The histone methyltransferase DOT1B is dispensable for stage differentiation and macrophage infection of

Nicole Eisenhuth, Elisa Theres Rauh, Melina Mitnacht, Andrea Debus, Ulrike Schleicher, Falk Butter, Katerina Pruzinova, Petr Volf, Christian J Janzen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in cellular and infection microbiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Nicole Eisenhuth *Department of Cell and Developmental Biology, Biocenter, University of Würzburg, Würzburg, Germany.
Elisa Theres Rauh *Department of Cell and Developmental Biology, Biocenter, University of Würzburg, Würzburg, Germany.
Melina MitnachtDepartment of Cell and Developmental Biology, Biocenter, University of Würzburg, Würzburg, Germany.
Andrea DebusMicrobiology Institute-Clinical Microbiology, Immunology and Hygiene, University Hospital Erlangen and Friedrich-Alexander-University, Erlangen, Germany.
Ulrike SchleicherMicrobiology Institute-Clinical Microbiology, Immunology and Hygiene, University Hospital Erlangen and Friedrich-Alexander-University, Erlangen, Germany.
Falk ButterProteomics und Systems Biology, Institute of Molecular Virology and Cell Biology (IMVZ), Friedrich Loeffler Institute, Greifswald, Germany.
Katerina PruzinovaDepartment of Parasitology, Charles University, Prague, Czechia.
Petr VolfDepartment of Parasitology, Charles University, Prague, Czechia.
Christian J JanzenDepartment of Cell and Developmental Biology, Biocenter, University of Würzburg, Würzburg, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Conserved histone methyltransferases of the DOT1 family are involved in replication regulation, cell cycle progression, stage differentiation, and gene regulation in trypanosomatids. However, the specific functions of these enzymes depend on the host evasion strategies of the parasites. In this study, we investigated the role of DOT1B in

Indexed as

Histone-Lysine N-MethyltransferaseLeishmania mexicanaMacrophagesProtozoan ProteinsAnimalsLife Cycle StagesMicePsychodidaeHistone-Lysine N-MethyltransferaseProtozoan ProteinsdifferentiationDOT1histone methyltransferaseLeishmania mexicanasand flyvirulence

Identifiers

PMID39902184
PMCPMC11788152

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.