Enhanced antitumor efficacy through sustained release of 5-fluorouracil from poly(trimethylene carbonate) membranes.

Zongheng Wang, Zhipeng Hou, Shuguang Zhang, Shuangyi Ren, Liqun Yang, Qianshi Zhang

Abstract read

In one paragraph

Article in Frontiers in pharmacology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Zongheng Wang *Department of Gastrointestinal Surgery, The Second Hospital of Dalian Medical University, Dalian, China.

Zhipeng Hou *Research Center for Biomedical Materials, Shenyang Key Laboratory of Biomedical Polymers, Engineering Research Center of Ministry of Education for Minimally Invasive Gastrointestinal Endoscopic Techniques, Shengjing Hospital of China Medical University, Shenyang, China.

Shuguang Zhang *Department of Thoracic Surgery, The First Affiliated Hospital of China Medical University, Shenyang, China.

Shuangyi RenDepartment of Gastrointestinal Surgery, The Second Hospital of Dalian Medical University, Dalian, China.

Liqun YangResearch Center for Biomedical Materials, Shenyang Key Laboratory of Biomedical Polymers, Engineering Research Center of Ministry of Education for Minimally Invasive Gastrointestinal Endoscopic Techniques, Shengjing Hospital of China Medical University, Shenyang, China.

Qianshi ZhangDepartment of Gastrointestinal Surgery, The Second Hospital of Dalian Medical University, Dalian, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Cancer remains one of the deadliest diseases worldwide. 5-Fluorouracil (5-FU) is one of the most commonly used chemotherapeutic agents in clinical practice today, but its effectiveness is often hampered by rapid drug metabolism and systemic toxicity. To address these limitations, the development of novel drug delivery systems for sustained drug release is essential to improve therapeutic outcomes. Methods: This study aimed to develop a poly(trimethylene carbonate) (PTMC) membrane capable of sustained drug release of 5-FU to enhance its antitumor activity. The membranes were prepared using the solvent-casting method, and their comprehensive properties were characterized. Results and Discussion: We evaluated the

Indexed as

5-fluorouracilantitumor efficacycolorectal cancerpoly(trimethylene carbonate)sustained drug release system

Identifiers

PMID39902070

DOI10.3389/fphar.2024.1536764

PMCPMC11788581

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