Evidence map›Paper›PMID 39902043›Full record

ArticleFrontiers in immunology2024

Heightened expression of type I interferon signaling genes in CD4

Elina El-Badry, Luxiao Chen, Khader Ghneim, Ziyi Li, Kelsie Brooks, Jake Rhodes, Rafick Sekaly, William Kilembe, Susan Allen, Hao Wu and 1 more

Abstract read
In one paragraph

Article in Frontiers in immunology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. The HIV Reservoir and Immune Landscape Across the Life Course of Women: Implications for Cure Strategies.American journal of reproductive immunology (New York, N.Y. : 1989) · 2026
    Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Elina El-Badry *Emory Vaccine Center, Emory National Primate Research Center, Emory University, Atlanta, GA, United States.
Luxiao Chen *Department of Biostatistics and Bioinformatics, Rollins School of Public Health, Emory University, Atlanta, GA, United States.
Khader GhneimDepartment of Pathology and Laboratory Medicine, Emory University, Atlanta, GA, United States.
Ziyi LiDepartment of Biostatistics and Bioinformatics, Rollins School of Public Health, Emory University, Atlanta, GA, United States.
Kelsie BrooksEmory Vaccine Center, Emory National Primate Research Center, Emory University, Atlanta, GA, United States.
Jake RhodesEmory Vaccine Center, Emory National Primate Research Center, Emory University, Atlanta, GA, United States.
Rafick SekalyDepartment of Pathology and Laboratory Medicine, Emory University, Atlanta, GA, United States.
William KilembeCenter for Family Health in Zambia, Lusaka, Zambia.
Susan AllenEmory Vaccine Center, Emory National Primate Research Center, Emory University, Atlanta, GA, United States.
Hao WuDepartment of Biostatistics and Bioinformatics, Rollins School of Public Health, Emory University, Atlanta, GA, United States.
Eric HunterEmory Vaccine Center, Emory National Primate Research Center, Emory University, Atlanta, GA, United States.

Funding

Yerkes National Primate Research Center Role of type-I IFN in regulating COVID-19 induced inflammation and pathogenesisP51OD011132 · OD · EMORY UNIVERSITY · PI Joon Sup Lee · 2012 to 2026
$167.0M
Virology and Molecular Biomarkers CoreP30AI050409 · NIAID · EMORY UNIVERSITY · PI Carlos del Rio · 2002 to 2026
$74.0M
Virologic Correlates of Heterosexual TransmissionR01AI051231 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI ALLEN, TODD M, HUNTER, ERIC · 2002 to 2022
$9.9M
Deciphering the impact of sex in early subtype C HIV infection and during HARTR01AI172740 · NIAID · EMORY UNIVERSITY · PI Eric Hunter · 2022 to 2026
$4.3M
VCT with Primary and Concurrent Partners to Prevent HIV Transmission R01MH095503 · NIMH · EMORY UNIVERSITY · PI ALLEN, SUSAN A · 2011 to 2016
$2.5M
Illumina NovaSeq 6000 High Throughput DNA Sequencer for Emory UniversityS10OD026799 · OD · EMORY UNIVERSITY · PI BOSINGER, STEVEN EDWARD · 2019 to 2019
$985k
NIAID NIH HHS P30 AI050409NIAID NIH HHS R01 AI051231NIAID NIH HHS R01 AI172740NIH HHS P51 OD011132NIH HHS S10 OD026799NIMH NIH HHS R01 MH095503
6 · The paper itself

Abstract

Sex differences play a role in the pathogenesis of a number of viral diseases. In HIV-1, several studies have reported that chronically infected women have significantly lower plasma viremia than men, although the exact mechanism by which this occurs has yet to be identified. We have performed bulk RNA-seq experiments comparing gene expression between CD4

Indexed as

CD4-Positive T-LymphocytesHIV-1HIV InfectionsInterferon Type ISignal TransductionViral LoadAcute DiseaseAdultFemaleGene Expression RegulationHumansMaleInterferon Type Iacute infectionHIVinterferonsex-based differencestranscriptomics

Identifiers

PMID39902043
PMCPMC11788160

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.