ArticleFrontiers in medicine2024
Association between platelet count and 30-day in-hospital mortality among intensive care unit patients with sepsis: a multicenter retrospective cohort study.
Article in Frontiers in medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- The incremental prognostic value of platelet-to-neutrophil and platelet-to-lymphocyte ratios in patients with sepsis: A retrospective cohort study.The Journal of international medical research · 2026Article
- Association between platelet count and 30-day mortality in community-acquired pneumonia patients receiving systemic glucocorticoids therapy.Scientific reports · 2026Article
- Platelet Recovery and Mortality in Septic Patients with Thrombocytopenia: A Propensity Score-Matched Analysis of the MIMIC-IV Database.Journal of clinical medicine · 2026Article
- Article
- Group-based trajectory modeling of platelet dynamics in sepsis: from phenotypic identification to the exploration of prognostic mediators.Frontiers in medicine · 2026Article
- Early dynamic changes in platelet counts and 28-day mortality in sepsis patients: a retrospective cohort study using dynamic latent class model and generalized additive mixture model analysis.Frontiers in medicine · 2025Article
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Authors and funding
5 authors.
Funding
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Abstract
Background: The relationship between platelet count and sepsis outcomes in intensive care units (ICUs) requires comprehensive investigation through large-scale multicenter studies. Methods: In this multicenter retrospective cohort study, we analyzed 17,977 sepsis patients from 208 U.S. hospitals (2014-2015) using the eICU Collaborative Research Database v2.0. Analyses were adjusted for demographics, clinical parameters, comorbidities, and treatments. Generalized additive models and two-piecewise linear regression were used to assess the relationship between platelet count and mortality. Results: A U-shaped relationship was identified with an inflection point at 176 × 10⁹/L. Below this threshold, each 10 × 10⁹/L increase in platelet count was associated with a 6% decrease in mortality risk (adjusted OR 0.94, 95% CI 0.93-0.95, Conclusion: This large-scale, multicenter retrospective study has made a significant contribution to understanding the association between platelet count and mortality in patients with sepsis in intensive care units. We identified a critical threshold of 176 × 10
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