Evidence map›Paper›PMID 39901991›Full record

ReviewCureus2025

Fecal Microbiota Transplantation as an Alternative Method in the Treatment of Obesity.

Shan Hemachandra, Sasanga N Rathnayake, Anne A Jayamaha, Bernadine S Francis, Dilitha Welmillage, Delvinderjit N Kaur, Hein K Zaw, Lin T Zaw, Hanna A Chandra, Maria E Abeysekera

Abstract readReview
In one paragraph

Review in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Shan HemachandraFamily Medicine, Nanjing Medical University, Nanjing, CHN.
Sasanga N RathnayakeGastroenterology, Nanjing Medical University, Nanjing, CHN.
Anne A JayamahaGastroenterology, Nanjing Medical University, Nanjing, CHN.
Bernadine S FrancisGastroenterology, Nanjing Medical University, Nanjing, CHN.
Dilitha WelmillageGastroenterology, Nanjing Medical University, Nanjing, CHN.
Delvinderjit N KaurGastroenterology, Nanjing Medical University, Nanjing, CHN.
Hein K ZawGastroenterology, Nanjing Medical University, Nanjing, CHN.
Lin T ZawGastroenterology, Nanjing Medical University, Nanjing, CHN.
Hanna A ChandraGastroenterology, Nanjing Medical University, Nanjing, CHN.
Maria E AbeysekeraFamily Medicine, Saint Agnes Hospital, Fresno, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Fecal microbiota transplantation (FMT) has emerged as a promising therapeutic approach for various health conditions, particularly obesity and metabolic disorders. This review examines the mechanisms underlying FMT, including its role in restoring gut microbiota diversity and enhancing immunomodulatory functions, which are essential for maintaining overall health. Recent studies indicate that FMT can significantly improve body weight and metabolic parameters, suggesting its potential as an alternative or complementary treatment to current obesity therapies. However, the effectiveness of FMT depends on several factors, including the composition of the donor microbiota, recipient characteristics, and concomitant medications or dietary interventions. Despite its great promise, challenges such as standardized protocols, donor screening, and the need for a deeper understanding of gut microbiota dynamics remain key hurdles. Future research should focus on elucidating the specific microbial compositions necessary for optimal therapeutic outcomes and exploring personalized FMT approaches tailored to individual patient profiles. This evolving field presents exciting opportunities for innovative strategies in obesity treatment, warranting further investigation and clinical application.

Indexed as

bacteroidetesclostridioides difficiledysbiosisfecal microbiota transplantation (fmt)gut-brain connectiongut dysbiosislean body massmicrobiotaobesityozempic for weight loss

Identifiers

PMID39901991
PMCPMC11788455

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.