ArticleFrontiers in surgery2025
Effect of epileptiform discharges and hippocampal volume on cognitive dysfunction following clipping of ruptured aneurysms in the anterior circulation.
Article in Frontiers in surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: Cognitive dysfunction after aneurysmal subarachnoid hemorrhage (aSAH) remains unclear due to various neurological impairments. This study aimed to evaluate the changes in hippocampal volume, cognitive function, and interictal epileptiform discharges after clipping in patients with aSAH of anterior circulation. Methods: Patients with modified Rankin Scale scores of 0-3 points who underwent clipping were evaluated. Aneurysmal locations were classified as middle cerebral artery (MCA), internal carotid artery (ICA), and anterior cerebral artery (ACA). Surgery was performed using the transsylvian approach or interhemispheric approach. Hippocampal volume measurement, neuropsychological assessments, and interictal electroencephalogram evaluations were performed postoperatively at the subacute phase. Epileptiform discharges were assessed using the spike index (SI). Results: We included 60 patients (23 men, 37 women; median age, 57.4 years). Aneurysmal locations were found in the MCA, ICA, and ACA in 23, 19, and 18 patients, respectively. The postoperative hippocampal volume was significantly reduced on the clipping approach side in the MCA and ICA groups (MCA, Discussion: Cognitive dysfunction in the subacute phase after clipping for aSAH was not correlated with hippocampal volume reduction but was correlated with interictal epileptiform discharges.
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